A receptor and neuron that activate a circuit limiting sucrose consumption

  1. Ryan M Joseph
  2. Jennifer S Sun
  3. Edric Tam
  4. John R Carlson  Is a corresponding author
  1. Yale University, United States

Abstract

The neural control of sugar consumption is critical for normal metabolism. In contrast to sugar-sensing taste neurons that promote consumption, we identify a taste neuron that limits sucrose consumption in Drosophila. Silencing of the neuron increases sucrose feeding; optogenetic activation decreases it. The feeding inhibition depends on the IR60b receptor, as shown by behavioral analysis and Ca2+ imaging of an IR60b mutant. The IR60b phenotype shows a high degree of chemical specificity when tested with a broad panel of tastants. An automated analysis of feeding behavior in freely moving flies shows that IR60b limits the duration of individual feeding bouts. This receptor and neuron provide the molecular and cellular underpinnings of a new element in the circuit logic of feeding regulation. We propose a dynamic model in which sucrose acts via IR60b to activate a circuit that inhibits feeding and prevents overconsumption.

Article and author information

Author details

  1. Ryan M Joseph

    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States
    Competing interests
    The authors declare that no competing interests exist.
  2. Jennifer S Sun

    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4274-0504
  3. Edric Tam

    Department of Biomedical Engineering, Yale University, New Haven, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. John R Carlson

    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States
    For correspondence
    john.carlson@yale.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0244-5180

Funding

National Institutes of Health

  • John R Carlson

National Institutes of Health

  • Ryan M Joseph

National Science Foundation

  • Jennifer S Sun

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Ronald L Calabrese, Emory University, United States

Version history

  1. Received: January 8, 2017
  2. Accepted: March 19, 2017
  3. Accepted Manuscript published: March 23, 2017 (version 1)
  4. Version of Record published: April 11, 2017 (version 2)

Copyright

© 2017, Joseph et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Ryan M Joseph
  2. Jennifer S Sun
  3. Edric Tam
  4. John R Carlson
(2017)
A receptor and neuron that activate a circuit limiting sucrose consumption
eLife 6:e24992.
https://doi.org/10.7554/eLife.24992

Share this article

https://doi.org/10.7554/eLife.24992

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