1. Cancer Biology
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Cancer Therapeutics: Partial loss of genes might open therapeutic window

  1. Bo Liu
  2. Omar Abdel-Wahab  Is a corresponding author
  1. Memorial Sloan Kettering Cancer Center, United States
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Cite this article as: eLife 2017;6:e25996 doi: 10.7554/eLife.25996
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Figures

Partial loss of SF3B1 and cancer.

Left: The gene SF3B1 encodes a protein (maroon) that is part of the SF3b complex (multiple colors), which is part of the spliceosome (not shown). Right: A significant number of cancer cells contain just one copy of SF3B1, rather than two, which leads to a reduced abundance of the SF3b complex in cells. Such cells are sensitive to further loss of SF3B1 through genetic down-regulation (top) or ubiquitination by a ligase (bottom). Cancer cells employ deubiquitinases to reverse the effects of ubiquitination, so drugs that inhibit these deubiquitinases could be used to treat some cancers. CYCLOPS: copy-number alterations yielding cancer liabilities owing to partial loss; DUBi: deubiquitinase inhibitor.

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