(A) Ion channel composition of the mouse dentate granule cell (GC) model. Left: Passive and active ion channels with their specific distribution in six different regions: outer molecular layer (OML), middle molecular layer (MML), inner molecular layer (IML), soma, axon initial segment (AIS) and axon. The relative spatial distribution of voltage-dependent (V.-dep.) and calcium-dependent (Ca2+-dep.) channels is in line with an extensive amount of data from the literature (see Table 1, Appendix 2 and Materials and methods for details). Right: Three exemplary morphologies out of eight reconstructed mouse GCs (Schmidt-Hieber et al., 2007) used for compartmental modeling of mouse GCs. (B) Schematic of the morphological model used to generate synthetic mouse morphologies which is analogous to the previously reported rat model (Beining et al., 2017; see Material and methods there for details). Upper left: A synthetic 3D young dentate gyrus (DG) was created comprising different layers (GCL, IML, MML, and OML, from bottom to top). A soma (red dot) was defined and random target points (black dots) were distributed within a 3D cone (red dashed lines). These points were complemented by directed target points (gray dots) that were placed automatically between clusters of target points and the soma. Upper right: The target points were connected by a minimum spanning tree algorithm (Cuntz et al., 2010) and terminal dendritic segments shorter than 20 µm were pruned off (red segments, see Beining et al., 2017). Lower right: The young DG and the dendritic tree have been stretched to their mature size (see Beining et al., 2017 for more information). Lower left: Adding a somatic diameter profile, a synthetic axon, applying jittering and dendritic diameter taper (not shown for visualization purposes) to the dendrites results in realistic synthetic GC morphologies suitable for compartmental modeling. (C) Six out of 15 synthetic morphologies created by the morphological model and used for compartmental modeling with their anatomical borders (gray dashed lines). (D) General and layer-specific structural comparison of the reconstructed (blue, Schmidt-Hieber et al., 2007) and synthetic (green) mouse GC morphologies.