Affective bias as a rational response to the statistics of rewards and punishments
Abstract
Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. Using a computational framework, we investigated whether affective biases may reflect individuals' estimates of the information content of negative relative to positive events. During a reinforcement learning task, the information content of positive and negative outcomes was manipulated independently by varying the volatility of their occurrence. Human participants altered the learning rates used for the outcomes selectively, preferentially learning from the most informative. This behaviour was associated with activity of the central norepinephrine system, estimated using pupilometry, for loss outcomes. Humans maintain independent estimates of the information content of distinct positive and negative outcomes which may bias their processing of affective events. Normalising affective biases using computationally inspired interventions may represent a novel approach to treatment development.
Article and author information
Author details
Funding
Medical Research Council (MR/N008103/1)
- Michael Browning
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Michael J Frank, Brown University, United States
Ethics
Human subjects: All participants provided written informed consent. The study was reviewed and approved by the Medical Sciences Interdepartmental Research Ethics Committee of Oxford University (ref number MSD-IDREC-C1-2014-216).
Version history
- Received: April 18, 2017
- Accepted: October 3, 2017
- Accepted Manuscript published: October 4, 2017 (version 1)
- Version of Record published: October 9, 2017 (version 2)
- Version of Record updated: October 19, 2017 (version 3)
Copyright
© 2017, Pulcu & Browning
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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