Exploratory search during directed navigation in C. elegans and Drosophila larva
- University of Miami, United States
- University of Leeds, United Kingdom
- Nanjing University, China
- Harvard University, United States
- Université de Strasbourg, France
Figures
Figure 1 with 1 supplement
Diffusive searching in C. elegans and Drosophila larva.
(A) Sample trajectories (left) from 18 worms under isotropic conditions, for 60 min. Tracks have been shifted to all begin at the same location for clarity. A single track (red) is magnified (right) …
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Figure 1—source data 1
Values and s.e.m. for diffusion coefficient vs. time plots
- https://doi.org/10.7554/eLife.30503.004
Figure 1—figure supplement 1
Consecutive run durations for individual C. elegans tracks under isotropic conditions.
56 sequences are shown (red), with a blue vertical line indicating the change point, found by maximizing the difference in average below and above a particular time in the experiment. Change …
Figure 2 with 1 supplement
Diffusion and navigation in C. elegans and Drosophila thermotaxis.
(A) Schematic of the apparatus (left), where animals crawl atop an agar substrate while exposed to a 1D linear temperature gradient. Sample thermotaxis trajectories (right) from 18 C. elegans …
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Figure 2—source data 1
Values and s.e.m. for diffusion coefficient vs. time plots
- https://doi.org/10.7554/eLife.30503.007
Figure 2—figure supplement 1
Reversability, detailed balance, and sampling intervals in the Markov state model approach.
(A) Analysis of the reversibility of the dynamics. Fluxes in positive (red) and negative (blue dashed) directions are shown. The topmost lines show and ; the lines are almost identical. The …
Figure 3
Diffusion and navigation in C. elegans salt chemotaxis.
(A) Sample trajectories (25 worms each) of crawling on an agar substrate with a salt concentration gradient increasing toward the right, under a low-salt concentration baseline (25 mM, left) and …
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Figure 3—source data 1
Values and s.e.m. for diffusion coefficient vs. time plots
- https://doi.org/10.7554/eLife.30503.009
Figure 4
Isothermal tracking in C. elegans includes diffusion in the -direction.
(A) Experimental trajectories under temperature gradient conditions, with worms initially placed at their cultivation temperature of 15°C. Colors are used for the reader to distinguish between …
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Figure 4—source data 1
Values and s.e.m. for diffusion coefficient vs. time plots
- https://doi.org/10.7554/eLife.30503.011
Additional files
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Source code 1
Scripts used in conjunction with MAGAT Analyzer software
- https://doi.org/10.7554/eLife.30503.012
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Transparent reporting form
- https://doi.org/10.7554/eLife.30503.013
