Exploratory search during directed navigation in C. elegans and Drosophila larva

  1. Mason Klein  Is a corresponding author
  2. Sergei V Krivov  Is a corresponding author
  3. Anggie J Ferrer
  4. Linjiao Luo
  5. Aravinthan DT Samuel
  6. Martin Karplus  Is a corresponding author
  1. University of Miami, United States
  2. University of Leeds, United Kingdom
  3. Nanjing University, China
  4. Harvard University, United States
  5. Université de Strasbourg, France
4 figures and 2 additional files

Figures

Figure 1 with 1 supplement
Diffusive searching in C. elegans and Drosophila larva.

(A) Sample trajectories (left) from 18 worms under isotropic conditions, for 60 min. Tracks have been shifted to all begin at the same location for clarity. A single track (red) is magnified (right) …

https://doi.org/10.7554/eLife.30503.002
Figure 1—source data 1

Values and s.e.m. for diffusion coefficient vs. time plots

https://doi.org/10.7554/eLife.30503.004
Figure 1—figure supplement 1
Consecutive run durations for individual C. elegans tracks under isotropic conditions.

56 sequences are shown (red), with a blue vertical line indicating the change point, found by maximizing the difference in average Δt below and above a particular time in the experiment. Change …

https://doi.org/10.7554/eLife.30503.003
Figure 2 with 1 supplement
Diffusion and navigation in C. elegans and Drosophila thermotaxis.

(A) Schematic of the apparatus (left), where animals crawl atop an agar substrate while exposed to a 1D linear temperature gradient. Sample thermotaxis trajectories (right) from 18 C. elegans

https://doi.org/10.7554/eLife.30503.005
Figure 2—source data 1

Values and s.e.m. for diffusion coefficient vs. time plots

https://doi.org/10.7554/eLife.30503.007
Figure 2—figure supplement 1
Reversability, detailed balance, and sampling intervals in the Markov state model approach.

(A) Analysis of the reversibility of the dynamics. Fluxes in positive (red) and negative (blue dashed) directions are shown. The topmost lines show J+(x) and J-(x); the lines are almost identical. The …

https://doi.org/10.7554/eLife.30503.006
Diffusion and navigation in C. elegans salt chemotaxis.

(A) Sample trajectories (25 worms each) of crawling on an agar substrate with a salt concentration gradient increasing toward the right, under a low-salt concentration baseline (25 mM, left) and …

https://doi.org/10.7554/eLife.30503.008
Figure 3—source data 1

Values and s.e.m. for diffusion coefficient vs. time plots

https://doi.org/10.7554/eLife.30503.009
Isothermal tracking in C. elegans includes diffusion in the x-direction.

(A) Experimental trajectories under temperature gradient conditions, with worms initially placed at their cultivation temperature of 15°C. Colors are used for the reader to distinguish between …

https://doi.org/10.7554/eLife.30503.010
Figure 4—source data 1

Values and s.e.m. for diffusion coefficient vs. time plots

https://doi.org/10.7554/eLife.30503.011

Additional files

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