1. Chromosomes and Gene Expression
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Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response

  1. Seunghee Oh
  2. Tamaki Suganuma  Is a corresponding author
  3. Madelaine M Gogol
  4. Jerry L Workman  Is a corresponding author
  1. Stowers Institute for Medical Research, United States
Research Article
  • Cited 8
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Cite this article as: eLife 2018;7:e36157 doi: 10.7554/eLife.36157
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Abstract

Upon nutritional stress, the metabolic status of cells is changed by nutrient signaling pathways to ensure survival. Altered metabolism by nutrient signaling pathways has been suggested to influence cellular lifespan. However, it remains unclear how chromatin regulation is involved in this process. Here, we found that histone H3 threonine 11 phosphorylation (H3pT11) functions as a marker for nutritional stress and aging. Sch9 and CK2 kinases cooperatively regulate H3pT11 under stress conditions. Importantly, H3pT11 defective mutants prolonged chronological lifespan (CLS) by altering nutritional stress responses. Thus, the phosphorylation of H3T11 by Sch9 and CK2 links a nutritional stress response to chromatin in the regulation of CLS.

Data availability

Sequencing data has been deposited at NCBI Dataset ID: GSE111219

The following data sets were generated

Article and author information

Author details

  1. Seunghee Oh

    Stowers Institute for Medical Research, Kansas City, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6701-9473
  2. Tamaki Suganuma

    Stowers Institute for Medical Research, Kansas City, United States
    For correspondence
    tas@stowers.org
    Competing interests
    No competing interests declared.
  3. Madelaine M Gogol

    Stowers Institute for Medical Research, Kansas City, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8738-0995
  4. Jerry L Workman

    Stowers Institute for Medical Research, Kansas City, United States
    For correspondence
    jlw@Stowers.org
    Competing interests
    Jerry L Workman, Reviewing editor, eLife.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8163-1952

Funding

Stowers Institute for Medical Research (Workman Lab)

  • Jerry L Workman

National Institute of General Medical Sciences (NIH R35 GM118068)

  • Jerry L Workman

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Matt Kaeberlein, University of Washington, United States

Publication history

  1. Received: February 22, 2018
  2. Accepted: June 23, 2018
  3. Accepted Manuscript published: June 25, 2018 (version 1)
  4. Version of Record published: July 12, 2018 (version 2)

Copyright

© 2018, Oh et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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