TFAP2 transcription factors are regulators of lipid droplet biogenesis

  1. Cameron C Scott
  2. Stefania Vossio
  3. Jacques Rougemont
  4. Jean Gruenberg  Is a corresponding author
  1. University of Geneva, Switzerland

Abstract

How trafficking pathways and organelle abundance adapt in response to metabolic and physiological changes is still mysterious, although a few transcriptional regulators of organellar biogenesis have been identified in recent years. We previously found that the Wnt signaling directly controls lipid droplet formation, linking the cell storage capacity to the established functions of Wnt in development and differentiation. In the present paper, we report that Wnt-induced lipid droplet biogenesis does not depend on the canonical TCF/LEF transcription factors. Instead, we find that TFAP2 family members mediate the pro-lipid droplet signal induced by Wnt3a, leading to the notion that the TFAP2 transcription factor may function as a 'master' regulator of lipid droplet biogenesis.

Data availability

All data generated or analysed during this study are included in the manuscript and supporting file. RNAseq data have been deposited under accession number E-MTAB-6623.

The following data sets were generated

Article and author information

Author details

  1. Cameron C Scott

    Department of Biochemistry, University of Geneva, Geneva, Switzerland
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-5026-3413
  2. Stefania Vossio

    Department of Biochemistry, University of Geneva, Geneva, Switzerland
    Competing interests
    The authors declare that no competing interests exist.
  3. Jacques Rougemont

    Department of Theoretical Physics, University of Geneva, Geneva, Switzerland
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0955-606X
  4. Jean Gruenberg

    Department of Biochemistry, University of Geneva, Geneva, Switzerland
    For correspondence
    jean.gruenberg@unige.ch
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0300-4862

Funding

Swiss National Science Foundation (310030B_141173)

  • Jean Gruenberg

NCCR Chemical Biology

  • Jean Gruenberg

Swiss SystemsX.ch Initiative evaluated by the Swiss National Science Foundation (LipidX)

  • Jean Gruenberg

Human Frontier Science Program (Fellowship)

  • Cameron C Scott

Canadian Institutes of Health Research (Fellowship)

  • Cameron C Scott

Swiss National Science Foundation (31003A_159479)

  • Jean Gruenberg

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Tobias C Walther, Harvard T. H. Chan School of Public Health, United States

Publication history

  1. Received: March 1, 2018
  2. Accepted: September 26, 2018
  3. Accepted Manuscript published: September 26, 2018 (version 1)
  4. Version of Record published: October 3, 2018 (version 2)

Copyright

© 2018, Scott et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Cameron C Scott
  2. Stefania Vossio
  3. Jacques Rougemont
  4. Jean Gruenberg
(2018)
TFAP2 transcription factors are regulators of lipid droplet biogenesis
eLife 7:e36330.
https://doi.org/10.7554/eLife.36330
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