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Intrinsically regulated learning is modulated by synaptic dopamine signaling

  1. Pablo Ripollés  Is a corresponding author
  2. Laura Ferreri
  3. Ernest Mas-Herrero
  4. Helena Alicart
  5. Alba Gómez-Andrés
  6. Josep Marco-Pallares
  7. Rosa Maria Antonijoan
  8. Toemme Noesselt
  9. Marta Valle
  10. Jordi Riba
  11. Antoni Rodriguez-Fornells  Is a corresponding author
  1. L’Hospitalet de Llobregat, Spain
  2. Campus Bellvitge, University of Barcelona, L’Hospitalet de Llobregat, Spain
  3. New York University, United States
  4. McGill University, Canada
  5. International Laboratory for Brain, Music, and Sound Research, Canada
  6. Centre for Research on Brain, Language and Music, Canada
  7. Universitat Autònoma de Barcelona, Spain
  8. Servei de Farmacologia Clínica, Hospital de la Santa Creu i Sant Pau, Spain
  9. Otto-von-Guericke University, Leipziger Straße, Germany
  10. Otto-von-Guericke-University Magdeburg, Postfach, Germany
  11. Center for Behavioral Brain Sciences, Germany
  12. Sant Pau Institute of Biomedical Research, Spain
  13. Catalan Institution for Research and Advanced Studies, Spain
Research Advance
Cite this article as: eLife 2018;7:e38113 doi: 10.7554/eLife.38113
3 figures, 1 table and 1 additional file

Figures

Figure 1 with 1 supplement
Effects of the pharmacological intervention (mean ± SEM) in (a) Learning and memory scores and (b) subjective ratings.

Note that subjective ratings were only measured during the learning phase of Day 1. Effects are calculated as % of change with respect to the placebo session. *p<0.05, **p<0.01.

https://doi.org/10.7554/eLife.38113.002
Figure 1—figure supplement 1
Mean plus standard error of the mean M+ scores for risperidone (black), placebo (white) and levodopa (grey) interventions separately for (A) learning and memory measures, (B) learning and memory measures separated for high (H+; black line) and low (H-; grey line) hedonic participants and (C) subjective ratings.
https://doi.org/10.7554/eLife.38113.003
Figure 2 with 2 supplements
Relation between the effect of the pharmacological intervention for the M+ condition and subjective sensitivity to reward for the learning scores (i.e., online Learning on Day 1, Words Remembered on Day 2; Recognition Rate on Day 2) obtained by (A) correlating drug effect and PAS scores (the lower the PAS values are, the higher the general hedonia); (B) computing the drug effect (mean ± SEM) according to high (Hedonic +) and low (Hedonic -) hedonic subjects (median split using the PAS).

*p<0.05, **p<0.001.

https://doi.org/10.7554/eLife.38113.004
Figure 2—figure supplement 1
Correlations between the PAS and the different measures of M+ learning and memory during risperidone, placebo or levodopa interventions.

Significant correlations (FDR-corrected for multiple comparisons) are marked in bold letters and with a red line.

https://doi.org/10.7554/eLife.38113.005
Figure 2—figure supplement 2
Correlations between the PAS and the M+ subjective ratings during risperidone, placebo or levodopa interventions.

Significant correlations (FDR-corrected for multiple comparisons) are marked in bold letters and with a red line.

https://doi.org/10.7554/eLife.38113.006
Author response image 1
Correlations between the PAS and the drug effect (calculated as the difference in percentage of change from the placebo session between levodopa and risperidone) with the anhedonic participant (marked with a red circle) included.
https://doi.org/10.7554/eLife.38113.012

Tables

Appendix 2—table 1
Counterbalancing across treatments, with six different sequences of letters randomly assigned to N = 30.

A corresponded to risperidone, B to placebo and C to levodopa.

https://doi.org/10.7554/eLife.38113.010
VolunteerSequenceTreatment order
15B/A/C
24A/C/B
35B/A/C
46C/B/A
52B/C/A
62B/C/A
72B/C/A
86C/B/A
91A/B/C
105B/A/C
113C/A/B
125B/A/C
133C/A/B
144A/C/B
151A/B/C
161A/B/C
172B/C/A
185B/A/C
191A/B/C
203C/A/B
214A/C/B
226C/B/A
234A/C/B
246C/B/A
256C/B/A
263C/A/B
271A/B/C
284A/C/B
292B/C/A
303C/A/B

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