(A) Number of small-scale studies implicating each gene in SCI pathophysiology in the LC gene set. (B) Experimental techniques used to associate LC genes with response to SCI in the LC gene set. (C) Enrichment for shared Gene Ontology terms among LC genes (all p < 10−15). BP, biological process; CC, cellular component; MF, molecular function. (D) Number of protein-protein interactions (PPIs) between LC genes observed in the high-confidence human interactome (Menche et al., 2015) (dotted line) and 1000 randomized interactome networks (density), revealing significant enrichment for PPIs between LC genes relative to random expectation (p < 10−3). (E) Size of the largest connected component (LCC) between LC genes in the high-confidence human interactome (dotted line) and 1000 randomized interactome networks (density), revealing LC genes occupy a distinct region of the human interactome (p < 10−3). (F) LC genes are prioritized by a disease gene prediction algorithm (Ghiassian et al., 2015) (p < 10−15, Kolmogorov–Smirnov test).