(A) Schematic illustration of the methods. The icons show a band-pass noise stimulus shown to either eye through the MR compatible goggles. Before and after the Pre- and Post-deprivation scans, outside the bore, we also measured binocular rivalry. (B) BOLD responses evoked by our band-pass noise stimulus with peak frequency 2.7 cycles per degree (cpd), presented in the deprived eye PRE-deprivation, mapped on the flattened cortical surface, cut at the calcarine sulcus. T-values are obtained by aligning GLM betas for each subject and hemisphere to a left/right symmetric template hemisphere, excluding vertices for which preferred eccentricity was not adequately estimated or smaller than 1 (the same criterion used for al analyses), then evaluating the distribution of betas in each vertex against 0 (one-sample t-test) and FDR correcting across the entire cortical surface. Black dashed lines show the approximate average location of the regions of interest V1 through MT, which were mapped on the individual subject spaces (see Materials and methods); white and blue lines represent the outer limits of the representation of our screen space (24 × 32 deg) and the foveal representation (≤1 deg, where eccentricity could not be mapped accurately) respectively. (C) BOLD modulation during the 3 TRs of stimulus presentation (from 0 to 9 s) and the following four blank TRs, for the 2.7 cpd noise stimuli delivered to the deprived eye before deprivation. The y-axis show the median percent BOLD signal change in V1 vertices relative to the signal at stimulus onset, averaged across subjects. Error bars give s.e. across participants. Note the small between-subject variability of the response (given that the response of each subject was computed for just two blocks of stimulation-blank). D: Average BOLD response to the band-pass noise stimulus with peak frequency 2.7 cpd, in each of the four conditions, computed by taking the median BOLD response across all V1 vertices then averaging these values across participants (after checking that distributions do not deviate from normality, Jarque-Bera hypothesis test of composite normality, all p > 0.06). The top black star indicates the significance of the ANOVA interaction between factors time (PRE, POST deprivation) and eye (deprived, non-deprived); the other stars report the results of post-hoc t-tests: red and green stars give the significance of the difference POST minus PRE, for the deprived and non-deprived eye respectively; bottom black stars give the significance of the difference deprived minus non-deprived eye before and after deprivation. *p < 0.05; **p < 0.01; ***p < 0.001; ns non-significant. E: Histograms of Ocular Drive Index: the difference between the response (GLM beta) to the deprived and non-deprived eye, computed for each vertex, separately before and after deprivation. Yellow and black lines give the median of the distributions, which are non-normal (logistic) due to excess kurtosis.