1. Biochemistry and Chemical Biology
  2. Human Biology and Medicine
Download icon

RNA-Binding Proteins: A matter of balance

  1. Aaron D Gitler  Is a corresponding author
  2. John D Fryer
  1. Stanford University School of Medicine, United States
  2. Mayo Clinic, United States
Insight
Cite this article as: eLife 2018;7:e40034 doi: 10.7554/eLife.40034
1 figure

Figures

Maintaining the balance of RNA-binding proteins.

(A) RNA-binding proteins (red, green, orange, purple, and blue), such as TDP-43 (green), regulate various RNA processing pathways, like the alternative splicing of mRNA. Many of these proteins are also prone to aggregating and becoming insoluble. As represented by the seesaw, this means that their concentration, solubility, and interactions with proteins must be controlled to maintain balance in the cell (right). Under normal conditions, TDP-43 is soluble and is mainly localized in the nucleus of the cell. (B) A mutation in a gene called C9orf72 can result in a reduction in the solubility of an RNA-binding protein known as hnRNP H (purple). This can also lead to changes in the concentration and solubility of other RNA-binding proteins (including TDP-43), which disrupts alternative splicing and other processes in the cell. The reduction in the solubility of TDP-43 causes it to accumulate in the cytoplasm, which is a hallmark of ALS and FTD. (C) Other triggers, such as genetic and environmental factors, can change the concentration and solubility of RNA-binding proteins (unbalanced seesaw); this causes them to misfold, become insoluble and accumulate in the cytoplasm.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)