(A) C9 (1, 2, and three equiv. ; blue, orange, and magenta, respectively) binds to native PPARγ (black), (B,C) but not when C9 (1 and 3 equiv.; blue and orange, respectively) binds to rosiglitazone-bound (two equiv.) PPARγ in the (B) delipidated or (C) native form. The black arrow denotes a peak present when PPARγ is bound to C9; grey arrows denote the lack of transition to a C9-bound peak, which is missing in the rosiglitazone-bound data (dotted circle/cross).