(A) Linear regression fits (line fill ±95% CI, error bars ± SEM) of the PAL total number of correct from 18 to 85 years old. FH led to lower PAL performance before 65 years of age (BFH = −2.39, pFH = 3.47e-06, FH +n = 14739, and FH- n = 50011). (B) Linear regression fits of the PAL total number of correct from 18 to 85 years old. Lines split by Sex and FH status. FH led to lower PAL performance, an effect that was exacerbated in men (BSex*FH = −0.79, pSex*FH = 7.97e-06, FH +Women n=11119, FH- Women n = 29332, FH +Men n=3617, and FH- Men n = 20678). The inset figure displays PSM box and whisker plots, split by sex, across each decade of life. The black bar through each box and whisker plot represents the median ATT for FH. Men had worse PAL scores when compared to women at each decade of life except for the sixth (60 s: Women[ATT-0.50 ± SD0.18], Men[ATT0.09 ± SD−0.36], women n = 40572, and men n = 24381).