This figure shows differential uptake of deuterium. In each case, the coloring scheme is as follows: no statistically different uptake (gray), regions missing peptide coverage(white), regions deleted in mutants (magenta), regions stabilized or protected from deuterium exchange (cool colors, as shown in the figure), and regions showing enhanced exchange correlating with enhanced dynamics (warm colors, as shown in the figure). (A) WT Rabex5 vs Rabex5:Rabaptin5 Complex, (B) WT Rabex5 vs RabexΔRpBD, (C) WT Rabex5:Rabaptin5 Complex vs RabexΔUBD:Rabaptin5 Complex, (D) WT Rabex5:Rabaptin5 Complex vs RabexΔLinker:Rabaptin5 Complex. Panel E shows another view of the differential deuterium uptake experiments. The data from panel A (orange), panel B (gray), panel C (blue), panel D (gold). This view highlights in which domain the differences in deuterium uptake can be found as it might not be readily apparent in the model views. The Rab5 binding sites within the Vps9 domain are highlighted.