1. Plant Biology
Download icon

Plant Stress: Hitting pause on the cell cycle

  1. Thomas Eekhout
  2. Lieven De Veylder  Is a corresponding author
  1. Ghent University, Belgium
  2. VIB Center for Plant Systems Biology, Belgium
Insight
Cite this article as: eLife 2019;8:e46781 doi: 10.7554/eLife.46781
1 figure

Figures

Hierarchical control of the DNA damage response in plants.

In plant cells, the kinases ATM and ATR are activated by different types of DNA damage. These enzymes go on to phosphorylate and activate the SOG1 transcription factor, which then binds to and switches on its target genes. These include (i) genes involved in DNA repair through homologous recombination (HR); (ii) the genes for ANAC044 and ANAC085, the newly identified transcription factors that help to stop the cell cycle; (iii) genes that trigger a cell death program (for when damage is too severe). ANAC044 and ANAC085 work by increasing the levels of Rep-MYB transcription factors. If stabilized, these proteins maintain the cells in the phase just before division (G2/M arrest) by binding to and repressing the genes essential for cell division to proceed. It is still unclear how Rep-MYBs are stabilized, or how SOG1 and ANAC044/ANAC085 may trigger cell death (Takahashi et al., 2019).

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)