1. Evolutionary Biology
  2. Genetics and Genomics
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Gene Drive: A family of killers

  1. Mickaël De Carvalho
  2. Sarah E Zanders  Is a corresponding author
  1. Stowers Institute for Medical Research, United States
  2. Open University, United Kingdom
  3. University of Kansas Medical Center, United States
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Cite this article as: eLife 2019;8:e49211 doi: 10.7554/eLife.49211
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Figures

Meiotic drive in Podospora anserina.

(A) A heterozygous diploid generated by mating a naïve strain to one carrying Spok2 undergoes meiosis and generates four spores. One possible outcome of meiosis is depicted. The spores that inherit Spok2 are alive (pigmented), while the spores that do not inherit the Spok2 gene are destroyed (unpigmented, hazard signs). (B) A heterozygous diploid generated by mating the Psk-1 strain (purple) to the Psk-7 strain (green) undergoes meiosis and generates four spores. Note that the Spok block (black oval) is on different chromosomes in the two isolates. Two possible outcomes are depicted: (left) all four spores survive because they all inherited Spok2 and the block that contains Spok3 and Spok4; (right) two of the four spores do not survive because they did not inherit the Spok block.

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