Saccade suppression depends on context

  1. Eckart Zimmermann  Is a corresponding author
  1. University of Düsseldorf, Germany

Abstract

Although our eyes are in constant movement, we remain unaware of the high-speed stimulation produced by the retinal displacement. Vision is drastically reduced at the time of saccades. Here, I investigated whether the reduction of the unwanted disturbance could be established through a saccade-contingent habituation to intra-saccadic displacements. In more than 100 context trials, participants were exposed either to an intra-saccadic or to a post-saccadic disturbance or to no disturbance at all. After induction of a specific context, I measured peri-saccadic suppression. Displacement discrimination thresholds of observers were high after participants were exposed to an intra-saccadic disturbance. However, after exposure to a post-saccadic disturbance or a context without any intra-saccadic stimulation, displacement discrimination improved such that observers were able to see shifts as during fixation. Saccade-contingent habituation might explain why we do not perceive trans-saccadic retinal stimulation during saccades.

Data availability

All measured data have been deposited in OSF under DOI 10.17605/OSF.IO/TZA7F.

The following data sets were generated

Article and author information

Author details

  1. Eckart Zimmermann

    Institute for Experimental Psychology, University of Düsseldorf, Düsseldorf, Germany
    For correspondence
    eckart.zimmermann@hhu.de
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-1964-2711

Funding

Deutsche Forschungsgemeinschaft (ZI/1456)

  • Eckart Zimmermann

H2020 European Research Council (757184)

  • Eckart Zimmermann

The funders supported the current study.

Reviewing Editor

  1. Marisa Carrasco, New York University, United States

Ethics

Human subjects: The study was approved by the ethics committee of the Faculty of Mathematics and Natural Sciences of the Heinrich-Heine-University Duesseldorf (ZI01-2019-01). Written informed consent about pseudonymized data collection, storage and publication was obtained prior to each experiment in accordance with the declaration of Helsinki.

Version history

  1. Received: June 26, 2019
  2. Accepted: March 2, 2020
  3. Accepted Manuscript published: March 5, 2020 (version 1)
  4. Accepted Manuscript updated: March 6, 2020 (version 2)
  5. Version of Record published: March 24, 2020 (version 3)
  6. Version of Record updated: March 27, 2020 (version 4)

Copyright

© 2020, Zimmermann

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 1,768
    Page views
  • 223
    Downloads
  • 10
    Citations

Article citation count generated by polling the highest count across the following sources: Crossref, PubMed Central, Scopus.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. Eckart Zimmermann
(2020)
Saccade suppression depends on context
eLife 9:e49700.
https://doi.org/10.7554/eLife.49700

Share this article

https://doi.org/10.7554/eLife.49700

Further reading

    1. Neuroscience
    Sydney Trask, Nicole C Ferrara
    Insight

    Gradually reducing a source of fear during extinction treatments may weaken negative memories in the long term.

    1. Cell Biology
    2. Neuroscience
    Haibin Yu, Dandan Liu ... Kai Yuan
    Research Article

    O-GlcNAcylation is a dynamic post-translational modification that diversifies the proteome. Its dysregulation is associated with neurological disorders that impair cognitive function, and yet identification of phenotype-relevant candidate substrates in a brain-region specific manner remains unfeasible. By combining an O-GlcNAc binding activity derived from Clostridium perfringens OGA (CpOGA) with TurboID proximity labeling in Drosophila, we developed an O-GlcNAcylation profiling tool that translates O-GlcNAc modification into biotin conjugation for tissue-specific candidate substrates enrichment. We mapped the O-GlcNAc interactome in major brain regions of Drosophila and found that components of the translational machinery, particularly ribosomal subunits, were abundantly O-GlcNAcylated in the mushroom body of Drosophila brain. Hypo-O-GlcNAcylation induced by ectopic expression of active CpOGA in the mushroom body decreased local translational activity, leading to olfactory learning deficits that could be rescued by dMyc overexpression-induced increase of protein synthesis. Our study provides a useful tool for future dissection of tissue-specific functions of O-GlcNAcylation in Drosophila, and suggests a possibility that O-GlcNAcylation impacts cognitive function via regulating regional translational activity in the brain.