(a) Mice were trained to use visual cues to navigate to a reward in a virtual-reality maze; neural population activity was recorded using Ca2+ imaging Driscoll et al., 2017. (b) (Reprinted from Driscoll et al., 2017) Neurons in PPC (vertical axes) fire at various regions in the maze (horizontal axes). Over days to weeks, individual neurons change their tuning, reconfiguring the population code. This occurs even at steady-state behavioral performance (after learning). (c) Each plot shows how location-averaged normalized activity changes for single cells over weeks. Missing days are interpolated to the nearest available sessions, and both left and right turns are combined. Neurons show diverse changes in tuning over days, including instability, relocation, long-term stability, gain/loss of selectivity, and intermittent responsiveness.
© 2017 Elsevier. Panel B reprinted from Driscoll et al., 2017 with permission from Elsevier. They are not covered by the CC-BY 4.0 licence and further reproduction of this panel would need permission from the copyright holder.