Integration of locomotion and auditory signals in the mouse inferior colliculus
- Institute for Basic Science (IBS), Republic of Korea
- School of Medicine, Sungkyunkwan University, Republic of Korea
- Sungkyunkwan University, Republic of Korea
Figures
Figure 1 with 1 supplement
Spontaneous activity of IC neurons is modulated by locomotion.
(A-B) Example recordings of spontaneous activity in IC neurons. During walking periods, the neuron in A increased firing (from 7.6 Hz to 21.6 Hz), whereas the neuron in B decreased firing (from 19.1 …
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Figure 1—source data 1
Source data for spontaneous activity modulation, and walking sound recording and playback.
- https://cdn.elifesciences.org/articles/52228/elife-52228-fig1-data1-v2.xlsx
Figure 1—figure supplement 1
Recording of walking sounds and playback responses.
(A) Top: walking sound recording in sound pressure waveforms (black and green boxes denote 2 sec periods during baseline and walking, respectively, used for power spectrum calculation and playback). …
Figure 2
The onset of firing rate modulation precedes locomotion onset.
(A-B) Top: Example neural recordings, corresponding smoothed firing rates, and walking speed. Bottom: Spike rasters aligned at the onset of walking and the locomotion onset-triggered averages of …
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Figure 2—source data 1
Source data for locomotion onset-triggered firing rate averaging and neural modulation latencies.
- https://cdn.elifesciences.org/articles/52228/elife-52228-fig2-data1-v2.xlsx
Figure 3 with 1 supplement
Locomotion modulates spontaneous activity in hearing-impaired mice.
(A) Raster plots (30 trials shown for each level) and PSTHs of multi-unit responses to broadband sound (2–64 kHz, 50 msec duration) in the example sites from normal (left) and hearing-impaired …
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Figure 3—source data 1
Source data for the effects of deafening, locomotion-induced modulation in hearing-impaired mice, and comparison of modulation between normal and hearing-impaired mice.
- https://cdn.elifesciences.org/articles/52228/elife-52228-fig3-data1-v2.xlsx
Figure 3—figure supplement 1
Modulation of spontaneous activity is similar between normal and hearing-impaired mice.
(A) Proportions of the types of modulation: increased, decreased, or no change. Normal: n = 96; hearing impaired: n = 34. (B) Modulation index (MI) comparison between normal and hearing-impaired …
Figure 4 with 2 supplements
Sound-evoked activity of IC neurons is attenuated during locomotion.
(A-C) Tone-evoked responses from three example IC neurons. Black spike rasters and PSTHs are from stationary trials, and green from walking trials. In each neuron, the same number of trials is shown …
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Figure 4—source data 1
Source data for modulation of sound-evoked responses during locomotion, relationships between spontaneous and evoked activity modulation, and spontaneous activity modulation in different response types.
- https://cdn.elifesciences.org/articles/52228/elife-52228-fig4-data1-v2.xlsx
Figure 4—figure supplement 1
Relationships between the locomotion-related modulation of spontaneous and tone-evoked activity.
(A-D) Tone-evoked responses in four example neurons with different types of spontaneous activity modulation during locomotion: increased (A-B), decreased (C), or no change (D). In raster plots and …
Figure 4—figure supplement 2
Spontaneous activity modulation during locomotion in neurons with different evoked response patterns.
(A) Proportions of modulation types in onset only (n = 29), sustained response (n = 34), or suppression only response type (n = 22). In the sustained group (center), the proportion of positive …
Tables
Key resources table
| Reagent type (species) or resource | Designation | Source or reference | Identifiers | Additional information |
|---|---|---|---|---|
| Strain, strain background (Mus musculus) | C57BL/6N | Orient Bio (Korea) | ||
| Genetic reagent (Mus musculus) | VGAT-ChR2-EYFP | The Jackson Laboratory | RRID:IMSR_JAX:0145498 | |
| Software, algorithm | MATLAB | MathWorks | RRID:SCR_001622 | All data analysis |
| Software, algorithm | Open Ephys GUI | Open Ephys | Neural data acquisition |
