(a) Exposing Aβ-CRY2-mCh C. elegans to blue light significantly reduced progeny numbers. Two-way ANOVA, p=0.1. Data were sampled over three days (Days 6–8), n = 8 light and dark worms. (b) MD-Gal4 driven Aβ-CRY2-mCh transgenic Drosophila produced significantly lower number of progeny when exposed to blue light. Two-way ANOVA ****p<0.0001. Data were sampled on Days 5, 6, 7, 13, 14, and 20, n = 25 light and dark pairs of Drosophila. (c) Aβ-CRY2-mCh C. elegans have significantly reduced locomotive ability when reared in light. Distance travelled was reduced by about three-folds compared to the dark control and non-heat shocked control. Data were sampled on Days 9 and 10, two-way ANOVA **p<0.01 n = 6 light, dark and non-heat shocked controls. (d) Climbing assay showed that transgenic Aβ Drosophila displayed sensorimotor impairments when exposed to light. Two-way ANOVA ****p<0.0001. n = 18 light and dark conditions.