(A) vWA domain architecture network of the MoxR-vWA-centric ternary systems. Domains linked in the same polypeptide are connected by arrows with the arrowhead pointing to the C-terminal domain. Node size is scaled based on the relative frequency of occurrence of the domain in the systems and edge thickness is scaled based on the relative frequency of edge occurrence. Edges with >148 occurrences are colored maroon, whereas those with >14 connections are shown in cadet blue, others are shown in grey. Functionally similar domains are identically colored as follows: blue, nucleotide-dependent signaling; purple, adaptor, superstructure-forming, and structural; dark red, peptidase; dark-green, DNA-targeting; light blue, cell division-related; yellow, apoptosis-related; orange, RNA-targeting; light green, macromolecule modification; red, miscellaneous effector. Further these have been grouped together to the extent possible and indicated on the network. (B) Generalized contextual diagram of VMAP architecture, as described in Figure 3B. (C) Detailed contextual diagram of the MoxR-vWA-centric ternary systems, depicting mutual exclusivity of components of peptide-modification accessory systems and the Trypco-trypsin and α/β hydrolase-CASPASE peptidase pairings. See 2B for convention. Arrow colors reflect the distinctness of the contexts. (D) FGS domain architectural subnetwork of the VMAP ternary systems depicting its diverse domain associations.