Patterned perturbation of inhibition can reveal the dynamical structure of neural processing

  1. Sadra Sadeh  Is a corresponding author
  2. Claudia Clopath
  1. Imperial College London, United Kingdom

Abstract

Perturbation of neuronal activity is key to understanding the brain's functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target neurons to reveal more specific cortical function. Here, we argue that patterned perturbation of neurons is in fact necessary to reveal the specific dynamics of inhibitory stabilization, emerging in cortical networks with strong excitatory and inhibitory functional subnetworks, as recently reported in mouse visual cortex. We propose a specific perturbative signature of these networks and investigate how this can be measured under different experimental conditions. Functionally, rapid spontaneous transitions between selective ensembles of neurons emerge in such networks, consistent with experimental results. Our study outlines the dynamical and functional properties of feature-specific inhibitory-stabilized networks, and suggests experimental protocols that can be used to detect them in the intact cortex.

Data availability

All data generated or analysed during this study are included in the manuscript and supporting files.

Article and author information

Author details

  1. Sadra Sadeh

    Bioengineering, Imperial College London, London, United Kingdom
    For correspondence
    s.sadeh@imperial.ac.uk
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8159-5461
  2. Claudia Clopath

    Department of Bioengineering, Imperial College London, London, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-4507-8648

Funding

Biotechnology and Biological Sciences Research Council (BB/N013956/1)

  • Claudia Clopath

Biotechnology and Biological Sciences Research Council (BB/N019008/1)

  • Claudia Clopath

Wellcome (200790/Z/16/Z)

  • Claudia Clopath

Simons Foundation (564408)

  • Claudia Clopath

Engineering and Physical Sciences Research Council (EP/R035806/1)

  • Claudia Clopath

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Stephanie Palmer, University of Chicago, United States

Version history

  1. Received: October 15, 2019
  2. Accepted: February 19, 2020
  3. Accepted Manuscript published: February 19, 2020 (version 1)
  4. Version of Record published: April 23, 2020 (version 2)

Copyright

© 2020, Sadeh & Clopath

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Sadra Sadeh
  2. Claudia Clopath
(2020)
Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
eLife 9:e52757.
https://doi.org/10.7554/eLife.52757

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https://doi.org/10.7554/eLife.52757

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