1. Medicine
  2. Immunology and Inflammation
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Sepsis: Modelling survival

  1. Teresa A Zimmers  Is a corresponding author
  2. Leonidas G Koniaris
  1. Indiana University School of Medicine, United States
  2. Indiana University, United States
  3. Indiana University Purdue University Indianapolis, United States
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Cite this article as: eLife 2019;8:e52959 doi: 10.7554/eLife.52959
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A mouse model for studying sepsis survival.

Sepsis is a life-threatening illness that occurs when the immune system overreacts to an injury or infection. Patients with early diagnosis of sepsis who are treated in an intensive care unit (ICU) have a much greater chance of survival (green arrow). However, a significant number of survivors suffer from long-term debilitating effects (blue arrow) and late mortality (red arrow). To better understand how to treat these long-term effects, Owen et al. have developed a mouse model that replicates the treatment outcomes of patients who had survived sepsis: 16-month-old mice were given an injury that induced sepsis and then given the same fluids and drugs patients would receive when in the ICU. These mice exhibited the long-term muscle weakness that commonly occurs in sepsis survivors.

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