(A) Density maps depicting the distributions of different opsins expressing cones (M+ and S+) and different cone populations classified anatomically as: All, M+S+ (mixed), M+S-, S+M- (true S) cones in pigmented and albino mice (left and right side respectively). Each column shows different cone populations from the same retina and, at the bottom of each map is shown the number of quantified cones. Color scales are shown in the right panel of each row (from 0 [purple] to 17,300 [dark red] for all cone types except to 5000 cones/mm2 [dark red] for the true S-cones and M+S--cone in the albino strain). Retinal orientation depicted by D: dorsal, N: nasal, T: temporal, V: ventral. (B) Histogram showing the mean ± standard deviation of different cone subtypes for eight retinas per strain (Supplementary file 1B). The percentages of each cone subtype are indicated inside of each bar, where 100% indicates the total of the ‘all cones’ group. (C) Opsin expression profile across the different retinal quadrants (retinal scheme, DT: dorsotemporal, DN: dorsonasal, VT: ventrotemporal, VN: ventronasal). Line graphs show the spatial profile of relative opsins expression (mixed [gray], M+S- [green], true S-cones [magenta]), where the sum of these three cone populations at a given distance from the optic nerve (ON) head equals 100%. Black mouse: pigmented mouse strain, white mouse: albino mouse strain.