1. Epidemiology and Global Health
  2. Medicine
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A systematic review of population-based studies on lipid profiles in Latin America and the Caribbean

  1. Rodrigo M Carrillo-Larco  Is a corresponding author
  2. C Joel Benites-Moya
  3. Cecilia Anza-Ramirez
  4. Leonardo Albitres-Flores
  5. Diana Sánchez-Velazco
  6. Niels Pacheco-Barrios
  7. Antonio Bernabe-Ortiz
  1. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom
  2. CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Peru
  3. Universidad Católica Los Ángeles de Chimbote, Instituto de Investigación, Peru
  4. Facultad de Medicina de la Universidad Nacional de Trujillo, Peru
  5. Sociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Trujillo-SOCEMUNT, Peru
  6. Universidad Científica del Sur, Peru
Research Article
Cite this article as: eLife 2020;9:e57980 doi: 10.7554/eLife.57980
3 figures, 1 table and 2 additional files

Figures

Figure 1 with 1 supplement
Study selection process.
Figure 1—figure supplement 1
Selection process and number of data sources per year.

In this figure supplement, we show the number of data sources by country and year of data collection.

Trends in mean total cholesterol, LDL-Cholesterol, HDL-Cholesterol and triglycerides in Latin America and the Caribbean.

The solid blue line represents a linear regression trend. Year in the x-axis refers to data collection year. Countries within sub-regions are shown in Supplementary file 1, Table 5. Individual estimates are shown in Supplementary file 1, Table 2.

Trends in prevalence of high total cholesterol, high LDL-Cholesterol, low HDL-Cholesterol and high triglycerides in Latin America and the Caribbean. The solid blue line represents a linear regression trend.

Year in the x-axis refers to data collection year. Countries within sub-regions are shown in Supplementary file 1, Table 5. Studies included in this graphics are those with standard clinically relevant definitions. I.e., total cholesterol ≥150 mg/dl,≥200 mg/dl, or ≥240 mg/dl; LDL-Cholesterol ≥100 mg/dl,≥130 mg/dl, or ≥160 mg/dl; HDL-Cholesterol ≤40 mg/dl in men and ≤50 mg/dl in women; triglycerides ≥ 100 mg/dl,≥130 mg/dl,≥150 mg/dl, or ≥200 mg/dl. That is, prevalence estimates based on other definitions were excluded. Individual estimates are shown in Supplementary file 1, Table 3.

Tables

Table 1
Pooled mean and pooled prevalence estimates since 2005, random-effects meta-analysis.
Mean (mg/dl)Lower 95% confidence intervalUpper 95% confidence interval
Total cholesterol (37 studies)193.39189.10197.68
LDL-Cholesterol (30 studies)119.98116.08123.88
HDL-Cholesterol (42 studies)46.5544.9948.12
Triglycerides (39 studies)139.27130.57147.98
Prevalence (%)Lower 95% confidence intervalUpper 95% confidence interval
High total cholesterol - ≥ 200 mg/dl (six studies)34.0419.0449.04
High total cholesterol - ≥ 240 mg/dl (five studies)20.9713.5128.43
High LDL-Cholesterol - ≥ 130 mg/dl (two studies)40.4129.0551.78
High LDL-Cholesterol - ≥ 160 mg/dl (five studies)19.7311.5727.89
Low HDL-Cholesterol ≤ 40(men) and ≤50(women) (nine studies)48.2736.3160.22
High Triglycerides ≥ 150 mg/dl (12 studies)43.1235.4050.85
High Triglycerides ≥ 200 mg/dl (four studies)20.4816.2824.69

Additional files

Supplementary file 1

Word document with checklist for reporting of systematic reviews; search terms used; risk of bias assessment and rationale; table describing the selected studies along with references; table with the mean levels by selected study; table with prevalence estimates by selected study.

https://cdn.elifesciences.org/articles/57980/elife-57980-supp1-v1.docx
Transparent reporting form
https://cdn.elifesciences.org/articles/57980/elife-57980-transrepform-v1.docx

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