1. Cell Biology
Download icon

Bone: A role for fat precursors in the marrow

  1. Noriaki Ono  Is a corresponding author
  1. School of Dentistry, University of Michigan, United States
Insight
Cite this article as: eLife 2020;9:e58084 doi: 10.7554/eLife.58084
1 figure

Figures

MALP cells and the formation of bone and blood vessels in the bone marrow (Zhong et al., 2020).

Schematic view of bone (grey) and bone marrow (orange). Bone marrow contains many different types of mesenchymal stromal cells: these include mesenchymal progenitor cells (purple), pre-osteoblasts (green), and pre-adipocytes (red). Mesenchymal progenitor cells and pre-osteoblasts can both give rise to the osteoblasts that line the bone surface (smooth yellow cells) and to the osteocytes that are embedded within the bone (jagged yellow cells). A MALP cell is type of pre-adipocyte, and MALP cells that express a hormone called adiponectin have important roles in: i) maintaining the marrow vasculature (arrow-ended red lines); ii) preventing mesenchymal progenitor cells from differentiating into osteoblasts (flat-ended red lines).

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)