(A) Workflow showing the integration of four different loss-of-function screen datasets. (B) Venn diagram showing the overlap of cell lines between the four datasets analysed in this study. (C) …
(A) Scatterplot showing the genetic dependencies identified across all datasets. Each individual point represents a gene pair, the x-axis shows the common language effect size, and the y-axis shows …
(A) Scatterplot showing the genetic dependencies identified in the SCORE dataset. Each individual point represents a gene pair, the x-axis shows the common language effect size, and the y-axis shows …
(A) Dot plot showing the robust genetic dependencies identified for oncogenes. Each coloured circle indicates a robust genetic dependency, scaled according to the number of dataset pairs it was …
(A) Dot plot showing the reproducible genetic dependencies identified. Each coloured circle indicates a reproducible genetic dependency, scaled according to the number of dataset pairs it was …
(A) Simplified RAS/RAF/MEK/ERK pathway diagram. Protein names (e.g. MEK) are shown inside nodes, while associated gene names are shown adjacent (e.g. MAP2K1). Nodes are coloured according to their …
(A) Barchart showing the percentage of protein–protein interacting pairs observed among different groups of gene pairs. The groups represent all gene pairs tested, gene pairs found to be …
(A) Barchart showing the percentage of protein–protein interacting pairs observed among different groups of gene pairs. The groups represent all gene pairs tested, gene pairs found to be …
Histograms showing the overlap between 100 degree matched randomisations of the STRING medium confidence protein–protein interaction and discovered (A and B) and validated (C and D) genetic …
(A) Workflow - synthetic lethal interactions from CRISPR-Cas9 screens in three cell lines (Wang et al., 2019) were compared to identify reproducible synthetic lethal partners. These genes were then …
(A) Boxplots showing the association between VPS4B loss and VPS4A sensitivity in the discovery dataset (DRIVE) and two validation datasets (AVANA and SCORE). (B) Mean viability of HAP1 cells treated …
Driver gene alterations.
Selectively lethal genes.
Reproducible genetic dependencies.
Pathway enrichment of driver gene dependencies.
Protein–protein interaction enrichment.
Passenger gene loss alterations.
Passenger gene dependencies.
VPS4A_VPS4B and DDX5_DDX17 viability data.