A unique multi-synaptic mechanism involving acetylcholine and GABA regulates dopamine release in the nucleus accumbens through early adolescence in male rats
- Department of Translational Neuroscience, Wake Forest University School of Medicine, United States
- Department of Physiology, University of Kentucky College of Medicine, United States
Figures
Figure 1
Early adolescent male rats have decreased stimulated dopamine release in the nucleus accumbens core.
(A) Ex vivo fast scan cyclic voltammetry was used to compare the maximum concentration of evoked dopamine release in the nucleus accumbens core of adult (>P70) and early adolescent (P28-35) male …
Figure 2
Nicotinic acetylcholine receptors (nAChRs), and in particular α6-containing nAChRs, differentially regulate dopamine release in the nucleus accumbens core of adolescent male rats.
(A) Acetylcholine, signaling through nAChRs located on dopamine terminals, is an important regulator of local dopamine release (Rice and Cragg, 2004). There are three main types of nAChRs found in …
Figure 3
Dopamine release and α6-containing nAChR modulation of dopamine release do not differ between mid-adolescence and adulthood in male rats.
(A) Maximum concentration of stimulated dopamine release in the nucleus accumbens core did not differ between adult (>P70) and mid- adolescent (P39-42) male rats. (B) α-Ctx, a selective …
Figure 4
Differential modulation of dopamine release by α6-containing nAChRs in adolescent male rats is mediated through GABA receptor signaling.
(A) A schematic shows localization of nAChRs and GABA receptors in the NAc core. (B) Bath application of bicuculline (BIC; a selective GABAA receptor antagonist) and subsequent application of …
Figure 5
Differential effect of α6-containing nAChRs on GABA and dopamine release in the striatum of adult versus adolescent male rats.
A schematic shows the relationship between GABA interneurons, cholinergic interneurons (CINs), and dopamine (DA) varicosities in adult (left column) and adolescent (right column) rats before (top …
