1. Evolutionary Biology
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Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates

  1. Rylan Shearn
  2. Allison E Wright
  3. Sylvain Mousset
  4. Corinne Régis
  5. Simon Penel
  6. Jean-François Lemaitre
  7. Guillaume Douay
  8. Brigitte Crouau-Roy
  9. Emilie Lecompte
  10. Gabriel AB Marais  Is a corresponding author
  1. CNRS / Univ. Lyon 1, France
  2. University of Sheffield, United Kingdom
  3. University of Vienna, Austria
  4. Zoo de Lyon, France
  5. CNRS / Univ. Toulouse, France
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Cite this article as: eLife 2020;9:e63650 doi: 10.7554/eLife.63650

Abstract

Sex chromosomes are typically comprised of a non-recombining region and a recombining pseudoautosomal region. Accurately quantifying the relative size of these regions is critical for sex-chromosome biology both from a functional and evolutionary perspective. The evolution of the pseudoautosomal boundary (PAB) is well documented in haplorrhines (apes and monkeys) but not in strepsirrhines (lemurs and lorises). Here we studied the PAB of seven species representing the main strepsirrhine lineages by sequencing a male and a female genome in each species and using sex differences in coverage to identify the PAB. We found that during primate evolution, the PAB has remained unchanged in strepsirrhines whereas several recombination suppression events moved the PAB and shortened the pseudoautosomal region in haplorrhines. Strepsirrhines are well known to have much lower sexual dimorphism than haplorrhines. We suggest that mutations with antagonistic effects between males and females have driven recombination suppression and PAB evolution in haplorrhines.

Data availability

All the data generated in this study is available at NCBI (project # PRJNA482296)

The following data sets were generated
The following previously published data sets were used

Article and author information

Author details

  1. Rylan Shearn

    LBBE, CNRS / Univ. Lyon 1, Villeurbanne, France
    Competing interests
    The authors declare that no competing interests exist.
  2. Allison E Wright

    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
  3. Sylvain Mousset

    Faculty of Mathematics, University of Vienna, Vienna, Austria
    Competing interests
    The authors declare that no competing interests exist.
  4. Corinne Régis

    LBBE, CNRS / Univ. Lyon 1, Villeurbanne, France
    Competing interests
    The authors declare that no competing interests exist.
  5. Simon Penel

    LBBE, CNRS / Univ. Lyon 1, Villeurbanne, France
    Competing interests
    The authors declare that no competing interests exist.
  6. Jean-François Lemaitre

    LBBE, CNRS / Univ. Lyon 1, Villeurbanne, France
    Competing interests
    The authors declare that no competing interests exist.
  7. Guillaume Douay

    Zoo de Lyon, Lyon, France
    Competing interests
    The authors declare that no competing interests exist.
  8. Brigitte Crouau-Roy

    Laboratoire Evolution et Diversité Biologique, CNRS / Univ. Toulouse, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  9. Emilie Lecompte

    Laboratoire Evolution et Diversité Biologique, CNRS / Univ. Toulouse, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5711-7395
  10. Gabriel AB Marais

    LBBE, CNRS / Univ. Lyon 1, Villeurbanne, France
    For correspondence
    gabriel.marais@univ-lyon1.fr
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-2134-5967

Funding

Agence Nationale de la Recherche (ANR-­‐12-­‐ BSV7-­‐0002-­‐04)

  • Gabriel AB Marais

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Virginie Courtier-Orgogozo, Institut Jacques Monod - CNRS UMR7592 - Université Paris Diderot

Publication history

  1. Received: October 1, 2020
  2. Accepted: November 16, 2020
  3. Accepted Manuscript published: November 18, 2020 (version 1)
  4. Accepted Manuscript updated: November 19, 2020 (version 2)
  5. Version of Record published: December 4, 2020 (version 3)

Copyright

© 2020, Shearn et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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