Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

  1. Manoj K Rathinaswamy
  2. Zied Gaieb
  3. Kaelin D Fleming
  4. Chiara Borsari
  5. Noah J Harris
  6. Brandon J Moeller
  7. Matthias P Wymann
  8. Rommie E Amaro
  9. John E Burke  Is a corresponding author
  1. University of Victoria, Canada
  2. University of California, San Diego, United States
  3. University of Basel, Switzerland
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  1. Manoj K Rathinaswamy
  2. Zied Gaieb
  3. Kaelin D Fleming
  4. Chiara Borsari
  5. Noah J Harris
  6. Brandon J Moeller
  7. Matthias P Wymann
  8. Rommie E Amaro
  9. John E Burke
(2021)
Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors
eLife 10:e64691.
https://doi.org/10.7554/eLife.64691