Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

  1. Manoj K Rathinaswamy
  2. Zied Gaieb
  3. Kaelin D Fleming
  4. Chiara Borsari
  5. Noah J Harris
  6. Brandon J Moeller
  7. Matthias P Wymann
  8. Rommie E Amaro
  9. John E Burke  Is a corresponding author
  1. University of Victoria, Canada
  2. University of California, San Diego, United States
  3. University of Basel, Switzerland

Peer review process

This article was accepted for publication via eLife's original publishing model. eLife publishes the authors' accepted manuscript as a PDF only version before the full Version of Record is ready for publication. Peer reviews are published along with the Version of Record.

History

  1. Version of Record published
  2. Accepted Manuscript published
  3. Accepted
  4. Received

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. Manoj K Rathinaswamy
  2. Zied Gaieb
  3. Kaelin D Fleming
  4. Chiara Borsari
  5. Noah J Harris
  6. Brandon J Moeller
  7. Matthias P Wymann
  8. Rommie E Amaro
  9. John E Burke
(2021)
Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors
eLife 10:e64691.
https://doi.org/10.7554/eLife.64691

Share this article

https://doi.org/10.7554/eLife.64691