Stimulator of interferon genes (STING) plays an important role in innate immunity by controlling type I interferon response against invaded pathogens. In this work we describe a previously unknown role of STING in lipid metabolism in Drosophila. Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage and downregulated expression of lipid metabolism genes. We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. The deletion of Drosophila STING leads to disturbed ACC localization and decreased FASN enzyme activity. Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila.
All data generated or analysed during this study are included in the manuscript and supporting files and tables.
- Katarina Akhmetova
- Maxim Balasov
- Igor Chesnokov
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Raghu Padinjat, National Centre for Biological Sciences, India
© 2021, Akhmetova et al.
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