Drosophila STING protein has a role in lipid metabolism
Abstract
Stimulator of interferon genes (STING) plays an important role in innate immunity by controlling type I interferon response against invaded pathogens. In this work we describe a previously unknown role of STING in lipid metabolism in Drosophila. Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage and downregulated expression of lipid metabolism genes. We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. The deletion of Drosophila STING leads to disturbed ACC localization and decreased FASN enzyme activity. Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting files and tables.
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Author details
Funding
National Institute of General Medical Sciences (GM121449)
- Katarina Akhmetova
- Maxim Balasov
- Igor Chesnokov
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Raghu Padinjat, National Centre for Biological Sciences, India
Version history
- Preprint posted: February 5, 2021 (view preprint)
- Received: February 8, 2021
- Accepted: August 31, 2021
- Accepted Manuscript published: September 1, 2021 (version 1)
- Accepted Manuscript updated: September 2, 2021 (version 2)
- Version of Record published: September 15, 2021 (version 3)
Copyright
© 2021, Akhmetova et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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