Brain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and functional abnormalities are consistent/inconsistent across languages. In the current multimodal meta-analysis, we found convergent structural and functional alterations in the left superior temporal gyrus across languages, suggesting a neural signature of DD. We found greater reduction in grey matter volume and brain activation in the left inferior frontal gyrus in morpho-syllabic languages (e.g. Chinese) than in alphabetic languages, and greater reduction in brain activation in the left middle temporal gyrus and fusiform gyrus in alphabetic languages than in morpho-syllabic languages. These language differences are explained as consequences of being DD while learning a specific language. In addition, we also found brain regions that showed increased grey matter volume and brain activation, presumably suggesting compensations and brain regions that showed inconsistent alterations in brain structure and function. Our study provides important insights about the etiology of DD from a cross-linguistic perspective with considerations of consistency/inconsistency between structural and functional alterations.
All data generated or analysed during this study are included in the manuscript and supporting files. Meta-analysis data is deposited to Dryad.
meta-analysis dataDryad Digital Repository, doi:10.5061/dryad.0p2ngf222.
- Fan Cao
- Fan Cao
- Fan Cao
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Ruth de Diego-Balaguer, Universitat de Barcelona, Spain
© 2021, Yan et al.
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