1. Cell Biology
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Metabolism: A move in response to starvation

  1. Rebecca Martina Fausten
  2. Maria Bohnert  Is a corresponding author
  1. Institute of Cell Dynamics and Imaging, and the Cells in Motion Interfaculty Centre, University of Münster, Germany
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Cite this article as: eLife 2021;10:e69680 doi: 10.7554/eLife.69680
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Enzyme partitioning in the mevalonate pathway.

The enzyme HMG-CoA reductase (orange) is dispersed throughout the membrane of the endoplasmic reticulum (brown) in the presence of ample glucose (left), but it moves to a contact site between the cell nucleus and a lysosome-like organelle called the vacuole (green) in response to glucose deprivation (center). This nucleus-vacuole junction depends on two tether proteins, Vac8 (blue) and Nvj1 (red). The partitioning of HMG-CoA reductase to the contact site results in increased flux through the mevalonate pathway (right), and growth advantages once glucose becomes available again.

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