Metabolism: A move in response to starvation

When a yeast cell runs out of fuel, it can increase the flux through a central metabolic pathway by simply changing the location of an enzyme.
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Figures

Enzyme partitioning in the mevalonate pathway.

The enzyme HMG-CoA reductase (orange) is dispersed throughout the membrane of the endoplasmic reticulum (brown) in the presence of ample glucose (left), but it moves to a contact site between the cell nucleus and a lysosome-like organelle called the vacuole (green) in response to glucose deprivation (center). This nucleus-vacuole junction depends on two tether proteins, Vac8 (blue) and Nvj1 (red). The partitioning of HMG-CoA reductase to the contact site results in increased flux through the mevalonate pathway (right), and growth advantages once glucose becomes available again.

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  1. Rebecca Martina Fausten
  2. Maria Bohnert
(2021)
Metabolism: A move in response to starvation
eLife 10:e69680.
https://doi.org/10.7554/eLife.69680