The 102 DRR-pvT1 repeat patterns shown demonstrate the diversity among iciHHV-6B (inherited) and HHV-6B (acquired) genomes. 90 of the repeat patterns were unique. The TTAGGG and degenerate, telomere-like repeats present in the HHV-6B pvT1 region are color-coded as follows and as shown in Figure 1: dark green, TTAGGG; brown, CTAGGG; cyan, TTAGTG; yellow, TTACTG; dark yellow, ATAGAC; teal, CTAAGG; pink, CTATGG; lime green, TTATGG; blue, GTAGTG; peach, TTAGAG; red, GTCTGG. Black squares represent other, less common degenerate repeats, and white squares show where the sequence could not be determined accurately. Dashes between repeats were added to maximize alignment between samples allowing comparison between the proximal, central (highly variable), and distal (highly conserved) sections of DRR-pvT1. Repeat maps were grouped primarily based on the proximal section, then on less common features within the central or distal region, and finally by the length of the central region. 98 of the 102 DRR-pvT1 repeat patterns are from unrelated individuals and 4 are from children who have an acqHHV-6B that has a different DRR-pvT1 repeat pattern from their parents (blue diamonds). Colored arrows identify 12 repeats patterns found more than once in donors not known to be related. Among eight of the identical DRR-pvT1 repeat patterns (blue arrows), seven are in iciHHV-6B genomes predicted to be integrated in the 9q telomere and one in an acquired HHV-6B in SAL030. Two others, in NWA008 and DER512 from the UK, have a 17p iciHHV-6B integration and share identical DRR-pvT1 repeat patterns. In addition, the acquired HHV-6B strains in SAL023 and TEL-FA G1P1 share the same DRR-pvT1 repeat pattern. Black boxes surround repeat maps from iciHHV-6Bs predicted to have the same integration site, by whole viral genome sequence homology, fluorescent in situ hybridization (FISH), or subtelomere-iciHHV-6B junction sequence. Notably within integration groups there are often shared characteristic features in the DRR-pvT1 repeat patterns. Black dots indicate iciHHV-6B samples where DRR-pvT1 could not be used to predict the integration site confidently. For example, the DRR-pvT1 in iciHHV-6B in d32 has a unique distal section and is unlikely to share common ancestry with any of the other iciHHV-6B carriers analyzed. Yellow diamond identifies the DRR-pvT1 repeat pattern in family Rx-F3a, transmitted from iciHHV-6B mother to non-carrier son. This pvT1 repeat map is different from the other 101 maps shown here.