Mixed effects Cox proportional hazards analyses in Generation Scotland (n = 9537) tested the relationships between each of the 109 selected EpiScores and the incidence of 12 leading causes of morbidity (Supplementary file 1I-J). The basic model was adjusted for age and sex and yielded 294 associations between EpiScores and disease diagnoses, with false discovery rate (FDR)-adjusted p < 0.05. In the fully adjusted model, which included common risk factors as additional covariates (smoking, deprivation, educational attainment, body mass index (BMI), and alcohol consumption), 137 of the basic model associations remained significant with p < 0.05. In a sensitivity analysis, the addition of estimated white blood cells (WBCs) to the fully adjusted models led to the attenuation of 34 of the 137 associations. In a further sensitivity analysis, 81 associations remained after adjustment for both immune cell proportions and GrimAge acceleration.