Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice

  1. Romane Cecchi
  2. Fabien Vinckier
  3. Jiri Hammer
  4. Petr Marusic
  5. Anca Nica
  6. Sylvain Rheims
  7. Agnès Trebuchon
  8. Emmanuel J Barbeau
  9. Marie Denuelle
  10. Louis Maillard
  11. Lorella Minotti
  12. Philippe Kahane
  13. Mathias Pessiglione
  14. Julien Bastin  Is a corresponding author
  1. Grenoble Alpes University, France
  2. Université de Paris, France
  3. University Hospital in Motol, Czech Republic
  4. Centre Hospitalier Universitaire de Rennes, France
  5. Hospices Civils de Lyon, France
  6. Hôpital de la Timone, France
  7. CNRS, University of Toulouse Paul Sabatier, France
  8. Centre Hospitalier Universitaire de Toulouse, France
  9. University Hospital of Nancy, France
  10. Centre Hospitalier Universitaire de Grenoble, France
  11. Pitié-Salpêtrière Hospital, France

Abstract

Identifying factors whose fluctuations are associated with choice inconsistency is a major issue for rational decision theory. Here, we investigated the neuro-computational mechanisms through which mood fluctuations may bias human choice behavior. Intracerebral EEG data were collected in a large group of subjects (n = 30), while they were performing interleaved quiz and choice tasks that were designed to examine how a series of unrelated feedbacks affects decisions between safe and risky options. Neural baseline activity preceding choice onset was confronted first to mood level, estimated by a computational model integrating the feedbacks received in the quiz task, and then to the weighting of option attributes, in a computational model predicting risk attitude in the choice task. Results showed that 1) elevated broadband gamma activity (BGA) in the ventromedial prefrontal cortex (vmPFC) and dorsal anterior insula (daIns) was respectively signaling periods of high and low mood, 2) increased vmPFC and daIns BGA respectively promoted and tempered risk taking by overweighting gain versus loss prospects. Thus, incidental feedbacks induce brain states that correspond to different moods and bias the evaluation of risky options. More generally, these findings might explain why people experiencing positive (or negative) outcome in some part of their life tend to expect success (or failure) in any other.

Data availability

Due to ethical restrictions on data sharing, we are unable to share raw data for this manuscript to preserve participant anonymity. However, anonymized iEEG data in BIDS format can be made available upon request to the corresponding author (JB) and source data files with anonymized regression estimates are available for download.The custom codes used to (i) extract the different frequency envelopes, and in particular the broadband gamma activity (BGA), from the raw intracranial data, (ii) perform the regression analyses at recording site level, and (iii) compute the second level statistics (across all recording sites of a ROI) are available at: https://gitlab.com/romane-cecchi/publications-code/2022-ieeg-mood-and-risky-choice (Cecchi, 2022; copy archived at https://archive.softwareheritage.org/swh:1:dir:ec43d71a97bf2e3c56b38688eaea2dfde19ad573).

Article and author information

Author details

  1. Romane Cecchi

    Grenoble Alpes University, Grenoble, France
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6149-939X
  2. Fabien Vinckier

    Université de Paris, Paris, France
    Competing interests
    The authors declare that no competing interests exist.
  3. Jiri Hammer

    University Hospital in Motol, Prague, Czech Republic
    Competing interests
    The authors declare that no competing interests exist.
  4. Petr Marusic

    University Hospital in Motol, Prague, Czech Republic
    Competing interests
    The authors declare that no competing interests exist.
  5. Anca Nica

    Centre Hospitalier Universitaire de Rennes, Rennes, France
    Competing interests
    The authors declare that no competing interests exist.
  6. Sylvain Rheims

    Hospices Civils de Lyon, Lyon, France
    Competing interests
    The authors declare that no competing interests exist.
  7. Agnès Trebuchon

    Hôpital de la Timone, Marseille, France
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8632-3454
  8. Emmanuel J Barbeau

    Brain and Cognition Research Centre (CerCo), CNRS, University of Toulouse Paul Sabatier, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-0836-3538
  9. Marie Denuelle

    Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  10. Louis Maillard

    University Hospital of Nancy, Nancy, France
    Competing interests
    The authors declare that no competing interests exist.
  11. Lorella Minotti

    Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Competing interests
    The authors declare that no competing interests exist.
  12. Philippe Kahane

    Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Competing interests
    The authors declare that no competing interests exist.
  13. Mathias Pessiglione

    Pitié-Salpêtrière Hospital, Paris, France
    Competing interests
    The authors declare that no competing interests exist.
  14. Julien Bastin

    Grenoble Alpes University, Grenoble, France
    For correspondence
    julien.bastin@univ-grenoble-alpes.fr
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0533-7564

Funding

Université Grenoble Alpes (ANR-17-CE37-0018)

  • Julien Bastin

Université Grenoble Alpes (ANR-18-CE28-0016)

  • Julien Bastin

Université Grenoble Alpes (ANR-13-TECS-0013)

  • Philippe Kahane
  • Julien Bastin

The Czech Science Foundation (20-21339S)

  • Jiri Hammer

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Human subjects: All patients gave written, informed consent before their inclusion in the present study, which received approval from the local ethics committees (CPP 09-CHUG-12, study 0907; CPP18-001b / 2017-A03248-45; IRB00003888; CER No. 47-0913).

Reviewing Editor

  1. Thorsten Kahnt, National Institute on Drug Abuse Intramural Research Program, United States

Publication history

  1. Preprint posted: June 2, 2021 (view preprint)
  2. Received: July 23, 2021
  3. Accepted: July 12, 2022
  4. Accepted Manuscript published: July 13, 2022 (version 1)
  5. Version of Record published: August 3, 2022 (version 2)

Copyright

© 2022, Cecchi et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Romane Cecchi
  2. Fabien Vinckier
  3. Jiri Hammer
  4. Petr Marusic
  5. Anca Nica
  6. Sylvain Rheims
  7. Agnès Trebuchon
  8. Emmanuel J Barbeau
  9. Marie Denuelle
  10. Louis Maillard
  11. Lorella Minotti
  12. Philippe Kahane
  13. Mathias Pessiglione
  14. Julien Bastin
(2022)
Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice
eLife 11:e72440.
https://doi.org/10.7554/eLife.72440

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