(A) Age density distribution (x-axis) of each site (y-axis) in the full model train and test, clinical, and transfer validation set. (B) Age count distribution of the full sample (N=58,836). (C, D) …
Reference brain charts were transferred to several clinical samples (described in (A)). Patterns of extreme deviations were summarized for each clinical group and compared to matched control groups …
The distribution of evaluation metrics in four different test sets (full, mQC, patients, and transfer, see Materials and methods) separated into left and right hemispheres and subcortical regions, …
The patterns appear to be robust and consistent across the different test sets.
The code for creating this website can be found on GitHub (https://github.com/saigerutherford/brainviz-app; copy archived at swh:1:rev:021fff9a48b26f2d07bbb4b3fb92cd5202418905; Rutherford, 2022b).
mQC refers to the manual quality checked subset of the full sample. ‘All’ rows=Train+Test. Clinical refers to the transdiagnostic psychiatric sample (diagnostic details in Figure 2A).
N (subjects) | N (sites) | Sex (%F/%M) | Age (Mean, S.D) | ||
---|---|---|---|---|---|
Full | All | 58,836 | 82 | ||
Training set | 29,418 | 82 | 51.1/48.9 | 46.9, 24.4 | |
Test set | 29,418 | 82 | 50.9/49.1 | 46.9, 24.4 | |
mQC | All | 24,354 | 59 | ||
Training set | 12,177 | 59 | 50.2/49.8 | 30.2, 24.1 | |
Test set | 12,177 | 59 | 50.4/49.4 | 30.1, 24.2 | |
Clinical | Test set | 1985 | 24 | 38.9/61.1 | 30.5, 14.1 |
Transfer | Test set | 546 | 6 | 44.5/55.5 | 24.8, 13.7 |
Full Sample Description, per site, in the train, test, and clinical validation sets.
Manual Quality Checked (mQC) Sample Description, per site, train and test sets.
Transfer Test Set Sample Descriptions, per site.
Data were downloaded from https://openneuro.org/ (Markiewicz et al., 2021) and are shared on GitHub along with code to transfer to demonstrate how to re-use models on new data.