Peter R Millar
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
No competing interests declared.
Brian A Gordon
Department of Radiology, Washington University in St. Louis, St. Louis, United States
Competing interests
No competing interests declared.
Patrick H Luckett
Department of Neurosurgery, Washington University in St. Louis, St. Louis, United States
Competing interests
No competing interests declared.
Tammie LS Benzinger
Department of Radiology, Washington University in St. Louis, St. Louis, United States
Competing interests
Tammie LS Benzinger, received doses (AV45, AV1451) and partial support for PET scanning through an investigator-initiated research grant awarded to Washington University from Avid Radiopharmaceuticals (a wholly-owned subsidiary of Eli Lilly and Company). The author received consulting fees from Eisai, Siemens, and received payment for Biogen speaker's bureau. Tammie Benzinger acts as site investigator in clinical trials sponsored by Avid Radiopharmaceuticals, Eli Lilly and Company, Biogen, Eisai, Jaansen and Roche. The author has no other competing interests to declare..
Carlos Cruchaga
Department of Psychiatry, Washington University in St. Louis, Saint Louis, United States
Competing interests
Carlos Cruchaga, has received research support from Biogen, EISAI, Alector and Parabon. Carlos Cruchaga is a member of the advisory board of Vivid Genetics, Circular Genomics and Alector. The author has no other competing interests to declare..
Anne M Fagan
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
Anne M Fagan, has received consulting fees from DiamiR and Siemens Healthcare Diagnostics Inc. and has received consulting fees for participation on Scientific advisory boards for Roche Diagnostics, Genentech and Diadem. The author has received travel support for in-person attendance at ABC-DS Meeting/Retreat and travel support/honorarium for in-person attendance at Scientific Advisory Board meeting for South Texas Alzheimer's Disease Research Center (ADRC). The author has no other competing interests to declare..
Jason Hassenstab
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
Jason Hassenstab, has received consulting fees from Roche and Parabon Nanolabs. The author has no other competing interests to declare..
Richard J Perrin
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
No competing interests declared.
Suzanne E Schindler
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
Suzanne E Schindler, received personal honoraria for presenting lectures from the University of Wisconsin, St. Luke's Hospital, Houston Methodist Medical Center, personal Honoraria for serving on the Alzheimer Disease Center Clinical Task Force from University of Washington and personal honoraria for serving on the National Centralized Repository for Alzheimer's Disease biospecimen review committee from University of Indiana. The author received travel support from National Institute on Aging grant R01AG070941, and is a board member of the Greater Missouri Alzheimer's Association. The author received plasma Ab42/Ab40 data provided by C2N Diagnostics at no cost. No payments/research funding was provided by C2N Diagnostics. No gifts/financial incentives of any kind have been provided to Dr. Schindler by C2N Diagnostics. The author has no other competing interests to declare..
Ricardo F Allegri
Department of Cognitive Neurology, Institute for Neurological Research (FLENI), Buenos Aires, Argentina
Competing interests
No competing interests declared.
Gregory S Day
Department of Neurology, Mayo Clinic Florida, Jacksonville, United States
Competing interests
Gregory S Day, received fees for consulting and for acting as Dementia Topic Editor from DynaMed (EBSCO Health) and received fees for consulting, grant writing / implementation Parabon Nanonlabs. The author received payment for CME Content development from PeerView Media and Continuing Education Inc, payment for educational content development and focus group participation from Eli Lilly Co, and payment for continuum manuscript authorship from the American Academy of Neurology. The author received payment for expert testimony in the case of Wernicke encephalopathy from Barrow Law. Gregory S Day acts as Clinical Director for Anti-NMDA Receptor Encephalitis Foundation, Inc. The author has stock holdings at ANI Pharmaceuticals, Inc and stock options at Parabon Nanolabs. The author has no other competing interests to declare..
Martin Rhys Farlow
Department of Neurology, Indiana University, Bloomington, United States
Competing interests
Martin Rhys Farlow, received grants from AbbVie, Eisai, Novartis, ADCS Posiphen, Genentech and Suven Life Sciences (no grant numbers available). The author has received consulting fees from Artery Therapeutics, Avanir, Biogen, Cyclo Therapeutics, Green Valley, Lexeo, McClena, Nervive, Oligomerix, Pinteon, Prothena, Vaxinity, Athira, AZTherapies, Cognition Therapeutics, Gemvax, Ionis, Longeveron, Merck, Neurotrope Biosciences, Otsuka, Proclara and SToP-AD. The author has no other competing interests to declare..
Hiroshi Mori
Department of Clinical Neuroscience, Osaka Metropolitan University, Osaka, Japan
Competing interests
No competing interests declared.
Georg Nübling
Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
Competing interests
No competing interests declared.
The Dominantly Inherited Alzheimer Network
Randall J Bateman
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
Randall J Bateman, received funding and non-financial support for the DIAN-TU-001 trial from Avid Radiopharmaceuticals, and funding for the DIAN-TU-001 trial from Janssen, Hoffman La-Roche/Genentech, Eli Lilly & Co., Eisai, Biogen, AbbVie and Bristol Meyer Squibb. The author has equity ownership interest in C2N Diagnostics and receives royalty income based on technology (stable isotope labeling kinetics and blood plasma assay) licensed by Washington University to C2N Diagnostics. The author received International Conference Lecture Honoraria from Korean Dementia Association and Conference Lecture Honoraria from Weill Cornell Medical College. The author received support for travel expenses from Alzheimer's Association Roundtable and Duke Margolis Alzheimer's Roundtable. The author participates on an unpaid Advisory Board for Roche Gantenerumab Steering Committee and Biogen - Combination Therapy for Alzheimer's Disease, and participates on an unpaid Scientific Advisory Board for UK Dementia Research Institute at University College London and Stanford University, Next Generation Translational Proteomics for Alzheimer's and Related Dementias. The author receives an income from C2N Diagnostics for serving on the scientific advisory board. The author has received equipment and materials from Avid Radiopharmaceuticals, Eli Lilly & Co, Hoffman La-Roche, Eisai and Janssen. Unrelated to this article, Randall Bateman serves as principal investigator of the DIAN-TU, which is supported by the Alzheimer's Association, GHR Foundation, an anonymous organization and the DIAN-TU Pharma Consortium (Active: Eli Lilly and Company/Avid Radiopharmaceuticals, F. Hoffman-La Roche/Genentech, Biogen, Eisai, and Janssen. Previous: Abbvie, Amgen, AstraZeneca, Forum, Mithridion, Novartis, Pfizer, Sanofi, and United Neuroscience). In addition, in-kind support has been received from CogState and Signant Health. Unrelated to this article Randall Bateman has submitted the US nonprovisional patent application Methods for Measuring the Metabolism of CNS Derived Biomolecules In Vivo" and provisional patent application "Plasma Based Methods for Detecting CNS Amyloid Deposition". The author has no other competing interests to declare.".
John C Morris
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
John C Morris, has received consulting fees from Barcelona Brain Research Center BBRC and Native Alzheimer Disease-Related Resource Center in Minority Aging Research, Ext Adv Board. The author has received payment or honoraria for lectures from Montefiore Grand Rounds, NY and Tetra-Inst ADRC seminar series, Grand Rds, NY. The author has participated on the Research Strategy Council for the Cure Alzheimer's Fund, the Diverse VCID Observational Study Monitoring Board and the LEADS Advisory Board, Indiana University. The author has no other competing interests to declare..
Beau M Ances
Department of Neurology, Washington University in St. Louis, St. Louis, United States
Competing interests
No competing interests declared.
National Institutes of Health (P01-AG026276)
National Institutes of Health (P01-AG03991)
National Institutes of Health (P30-AG066444)
National Institutes of Health (5-R01-AG052550)
National Institutes of Health (5-R01-AG057680)
National Institutes of Health (U19-AG032438)
BrightFocus Foundation (A2022014F)
Alzheimer's Association (SG-20-690363-DIAN)
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Human subjects: All participants provided written informed consent in accordance with the Declaration of Helsinki and their local institutional review board. All procedures were approved by the Human Research Protection Office at WUSTL (IRB ID # 201204041).
© 2023, Millar et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.