Joint inference of evolutionary transitions to self-fertilization and demographic history using whole-genome sequences
- Max Planck Institute for Plant Breeding Research, Germany
- Technical University of Munich, Germany
- Université Rennes 1, CNRS, France
Abstract
The evolution from outcrossing to selfing is a transition that occurred recurrently throughout the eukaryote tree of life, in plants, animals, fungi and algae. Despite some short-term advantages, selfing is supposed to be an evolutionary dead-end reproductive strategy on the long-term and its tippy distribution on phylogenies suggests that most selfing species are of recent origin. However, dating such transitions is challenging while it is central for this hypothesis. We build on previous theories to explicit the differential effect of past changes in selfing rate or in population size on the probability of recombination events along the genome. This allows us to develop two methods making use of full genome polymorphism data to 1) test if a transition from outcrossing to selfing occurred, and 2) infer its age. The sequentially Markov coalescent based (teSMC) and the Approximate Bayesian Computation (tsABC) methods use a common framework based on a transition matrix summarizing the distribution of times to the most recent common ancestor along the genome, allowing to estimate changes in the ratio of population recombination and mutation rates in time. We first demonstrate that our methods can disentangle between past change in selfing rate from past changes in demographic history. Second, we assess the accuracy of our methods and show that transitions to selfing as old as approximatively 2.5Ne generations can be identified from polymorphism data. Third, our estimates are robust to the presence of linked negative selection on coding sequences. Finally, as a proof of principle, we apply both methods to three populations from Arabidopsis thaliana, recovering a transition to selfing which occurred approximately 600,000 years ago. Our methods pave the way to study recent transitions to predominant self-fertilization in selfing organisms and to better account for variation in mating systems in demographic inferences.
Data availability
The current manuscript is a computational study, so no data have been generated for this manuscript. Modelling code is available at the following repositories.tsABC: https://github.com/sstruett/tsABCteSMC: https://github.com/TPPSellinger/eSMC2scripts used for the analyses in Strütt and Sellinger et al: https://github.com/laurentlab-mpipz/struett_and_sellinger_et_al
-
1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana1001genomes, DOI: 10.1016/j.cell.2016.05.063.
Article and author information
Author details
Funding
Max Planck Institute for Plant Breeding Research (open access funding)
- Stefan Strütt
- Stefan Laurent
No external funding was received for this work.
Copyright
© 2023, Strütt et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 1,392
- views
-
- 165
- downloads
-
- 13
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Joint inference of evolutionary transitions to self-fertilization and demographic history using whole-genome sequences
eLife 12:e82384.
https://doi.org/10.7554/eLife.82384
Further reading
-
- Evolutionary Biology
The rise of angiosperms to ecological dominance and the breakup of Gondwana during the Mesozoic marked major transitions in the evolutionary history of insect-plant interactions. To elucidate how contemporary trophic interactions were influenced by host plant shifts and palaeogeographical events, we integrated molecular data with information from the fossil record to construct a time tree for ancient phytophagous weevils of the beetle family Belidae. Our analyses indicate that crown-group Belidae originated approximately 138 Ma ago in Gondwana, associated with Pinopsida (conifer) host plants, with larvae likely developing in dead/decaying branches. Belids tracked their host plants as major plate movements occurred during Gondwana’s breakup, surviving on distant, disjunct landmasses. Some belids shifted to Angiospermae and Cycadopsida when and where conifers declined, evolving new trophic interactions, including brood-pollination mutualisms with cycads and associations with achlorophyllous parasitic angiosperms. Extant radiations of belids in the genera Rhinotia (Australian region) and Proterhinus (Hawaiian Islands) have relatively recent origins.
-
- Evolutionary Biology
Studying the fecal microbiota of wild baboons helps provide new insight into the factors that influence biological aging.
