Flexible coding of time or distance in hippocampal cells
- Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Israel
- Center for Memory and Brain, Boston University, United States
- Department of Biomedical Engineering, Boston University, United States
- Tel Aviv Sourasky Medical Center, Israel
Figures
Figure 1
Experimental setup.
(a) The figure-eight maze with treadmill (gray belt) located in the central stem. Water ports are located near the treadmill and at the two lower corners of the maze. Blue line indicates …
Figure 2 with 1 supplement
Distance and time cells coding.
(a–h) Examples of two time-coding cells (columns 1–2) and two distance-coding cells (columns 3–4). Row a depicts neural firing as a function of the distance the animal traveled, sorted by the runs’ …
Figure 2—figure supplement 1
Additional examples of cells showing time coding (a–d) and distance encoding (e–h).
Rows a,e depict neural firing as a function of time, sorted by the run’s velocities. The colors represent three velocity groups for which the tuning curves, either by time or distance, are presented …
Figure 3 with 3 supplements
Distance and Time Cells classification.
(a) Cells type classified by the CellType metric, averaged over all animals and trials, for fixed-distance and fixed-time experiments (n=18 experiments, mean ± SEM) p<<0.001 by Pearson's chi-squared …
Figure 3—figure supplement 1
Additional metrics.
Cells type classified by the FIT metric (a) and p-Value metric (b), averaged over all animals and trials, for fixed distance and fixed time experiments (n=18 experiments, mean ± SEM) p<<0.001 by …
Figure 3—figure supplement 2
The distribution of Time and Place cells, per animal, at various metrics, for Time and Distance sessions.
Animals BK26 (n=3 experiments) and BK33 (n=1 experiment) participated only in distance sessions, while BK45 (n=3 experiments) participated only in a time session, and BK35 (n=3 experiments), BK41 …
Figure 3—figure supplement 3
Distribution of max and average firing rates for Time and Distance cells.
Total 304 time cells and 374 distance cells evaluated. The time cells and distance cells distributions are similar (p=0.975, Kolmogorov-Smirnov test for the max firing rate, p=0.675 for the average …
