Figure 5. | Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

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Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

Figure 5.

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University of California, San Francisco, United States; University of Pennsylvania, United States
Figure 5.
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Left: mean mutation frequencies for three parameter sets (‘low’, g¯ = 3.94; ‘best’, g¯ = 4.65; ‘high’, g¯ = 5.76). Mutation rate is 2 × 10−5 per replication event; ‘relative replication rate’ reflects the reduced probability of a mutant template to replicate, relative to an unmutated strand. Grey lines indicate the expected mean for each parameter set with no selection (deficit of zero); the black line shows the mutation rate in one replication step, and therefore the expected frequency when mutants cannot replicate. Bars indicate 95% confidence intervals. Right: distributions of g of progeny from single cell infections for three parameter sets (‘low’, g¯ = 3.94; ‘best’, g¯ = 4.65; ‘high’, g¯ = 5.76).

DOI: http://dx.doi.org/10.7554/eLife.03753.016