Figure 1. | Uncertainty leads to persistent effects on reach representations in dorsal premotor cortex

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Uncertainty leads to persistent effects on reach representations in dorsal premotor cortex

Figure 1.

Affiliation details

McCormick School of Engineering, Northwestern University, United States; Feinberg School of Medicine, Northwestern University, United States; Northwestern University, United States
Figure 1.
Download figureOpen in new tabFigure 1. Experimental setup and behavior.

(A) Monkeys made planar center-out reaches with instructed delay to visual targets. Illustrations on right show target locations (black) and reach trajectories (gray) for trials in the center out and uncertainty blocks for an example session. In the center-out block, targets were distributed uniformly across eight directions and were cued with no uncertainty. In the uncertainty block, targets were sampled from a von Mises distribution and cued with stochastically sampled lines with either low or high variance. (B) Scatter plots of cue centroid versus reach direction for three sessions, with each dot representing a single trial. Under high uncertainty, the endpoints reflected an increased bias toward the average target location – indicated by a reduction in slope – and increased variability surrounding the fit line. (C) With the exception of two datasets from monkey M, fits to the behavioral scatter plots reveal reduced slope (negative ∆cue weighting) for higher uncertainty targets. All datasets show greater residual variance with greater uncertainty.


Figure 1—source data 1.Experimental details for all sessions.

In some instances we obtained multiple sessions from the same day (sessions 3–4, 5–7, 8–10, 11–12, 13–14, 16–17, and 26–27). In these cases, the sessions shared the same sorted neurons and center out trials. Uncertain trial blocks could differ in either target distribution or visual cue properties.


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