Deep mutational scanning of a synthetic allosteric chimera revealed that a sparse set of mutations on the protein surface improved regulation.

PLC-γ isozymes are activated by a combination of receptor engagement and membrane proximity.

Structural and functional characterization of an unanticipated mode of allosteric activity regulation in ribonucleotide reductases controlled by an ATP-cone in the radical-generating subunit.

Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.

Internal dynamics play a crucial functional role in MarR (multiple antibiotic resistance repressor) proteins and their role reconciles the distinct allosteric mechanisms proposed previously.

The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically altered through evolution of enzyme oligomerization.

Cryo-EM structures of two types of prokaryotic Phosphoribosyl pyrophosphate synthase filaments reveal that filamentation into cytoophidia provides a new layer of metabolic regulation.

Understanding the complex auto-regulatory mechanisms for guanine nucleotide exchange factors is critically important for fully appreciating the layers of control for small GTPases.

Key allosteric residues are predicted based on sequence coevolution analysis, which serves as guidelines for allosteric drug design and optimization.

Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.