Inna Rozman Grinberg, Daniel Lundin ... Britt-Marie Sjöberg
Structural and functional characterization of an unanticipated mode of allosteric activity regulation in ribonucleotide reductases controlled by an ATP-cone in the radical-generating subunit.
The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
Daiana A Capdevila, Fidel Huerta ... David P Giedroc
Internal dynamics play a crucial functional role in MarR (multiple antibiotic resistance repressor) proteins and their role reconciles the distinct allosteric mechanisms proposed previously.
The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically altered through evolution of enzyme oligomerization.
Cryo-EM structures of two types of prokaryotic Phosphoribosyl pyrophosphate synthase filaments reveal that filamentation into cytoophidia provides a new layer of metabolic regulation.
Understanding the complex auto-regulatory mechanisms for guanine nucleotide exchange factors is critically important for fully appreciating the layers of control for small GTPases.