314 results found
    1. Neuroscience

    Rate and oscillatory switching dynamics of a multilayer visual microcircuit model

    Gerald Hahn, Arvind Kumar ... Gustavo Deco
    A computer model of the mouse visual cortex shows that local brain circuits are organized as switches whose states are coded as neuronal oscillations with different frequencies.
    1. Neuroscience

    Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit

    Eliot Dow, Adrian Jacobo ... A J Hudspeth
    The technique of serial blockface scanning electron microscopy, which permits the complete reconstruction of neuronal structures, allows comparison of the detailed "wiring diagrams" of lateral-line receptor organs in wild-type and mutant zebrafish.
    1. Neuroscience

    Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons

    Viktor J Oláh, Nigel P Pedersen, Matthew JM Rowan
    Artificial neural networks can faithfully recapitulate realistic neuronal behavior with dramatically accelerated simulation runtimes, empowering accessible large-scale realistic network simulations.
    1. Neuroscience

    High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

    Yangfan Peng, Franz Xaver Mittermaier ... Jörg Rolf Paul Geiger
    Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
    1. Neuroscience

    Laminar microcircuitry of visual cortex producing attention-associated electric fields

    Jacob A Westerberg, Michelle S Schall ... Jeffrey D Schall
    Simultaneous sampling of electrical voltages outside the brain with neural signals in the cerebral cortex reveals how electrical currents in mosaics of cortical columns produce an electrical signal that can be measured noninvasively to assess the allocation of attention.
    1. Neuroscience

    Automatic discovery of cell types and microcircuitry from neural connectomics

    Eric Jonas, Konrad Kording
    An algorithm for analysing brain connectivity data identifies cell types and connections in simple (C. elegans) and complex (mouse) nervous systems, and can even resolve structure and connectivity in a man-made microprocessor.
    1. Neuroscience

    Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection

    Tuan V Bui, Nicolas Stifani ... Robert M Brownstone
    A genetically-defined population of spinal interneurons is reciprocally connected with spinal locomotor circuits and mediates recovery of locomotor function following spinal cord transection.
    1. Neuroscience

    The inhibitory microcircuit of the substantia nigra provides feedback gain control of the basal ganglia output

    Jennifer Brown, Wei-Xing Pan, Joshua Tate Dudman
    Negative feedback signals within the substantia nigra regulate the output of the basal ganglia, with implications for disorders such as Parkinson's disease.
    1. Neuroscience

    Wiring variations that enable and constrain neural computation in a sensory microcircuit

    William F Tobin, Rachel I Wilson, Wei-Chung Allen Lee
    Systematic and coordinated variations in morphology and connectivity can structurally tune a microcircuit's computation but non-systematic variably also exists, imparting "connection noise" that potentially limits processing performance.
    1. Computational and Systems Biology
    2. Neuroscience

    An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster

    Evripidis Gkanias, Li Yan McCurdy ... Barbara Webb
    Modelling differential roles for identified dopaminergic and output neurons of the fruit fly mushroom bodies, combined with a novel dopaminergic plasticity rule, explains neural and behavioural phenomena in olfactory learning tasks.

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