Anthony W Azevedo, Evyn S Dickinson ... John C Tuthill
Motor neurons controlling the leg of the fruit fly exhibit a gradient of physiological and functional properties that correlate with the order in which they fire during behavior.
Disi An, Ryosuke Fujiki ... Esteban Orlando Mazzoni
Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
Neurons in motor cortex contain information about each arm, but these signals are separated into different dimensions, allowing separate control of each arm.
Alicia N Vagnozzi, Kiran Garg ... Polyxeni Philippidou
Molecular programs regulated by Hox5 transcription factors establish a set of inhibitory inputs onto phrenic motor neurons that control the pattern of respiratory motor output.
Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.