5,685 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance

    Rene Niehus, Esther van Kleef ... Ben S Cooper
    A data-driven within-host model reveals that different antibiotics are associated with divergent effects on antibiotic resistance carriage and abundance in hospitalised patients, with important implications for antibiotic stewardship.
    1. Cell Biology

    Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

    Daniel J Fazakerley, Rima Chaudhuri ... David E James
    Lower mitochondrial coenzyme Q was a consistent feature across multiple in vitro and in vivo models of insulin resistance and was sufficient to cause insulin resistance through increased mitochondrial oxidants.
    1. Epidemiology and Global Health

    Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance

    Qixin He, John K Chaillet, Frédéric Labbé
    A novel compartment model identifies the impact of malaria strain diversity on biogeographic drug resistance patterns, supported by empirical evidence.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of drug resistance in clinical isolates of Candida albicans

    Christopher B Ford, Jason M Funt ... Aviv Regev
    Loss-of-heterozygosity mutations, but not aneuploidies, are linked to the evolution of drug resistance in Candida albicans isolated from immunocompromised patients.
    1. Evolutionary Biology

    Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

    Claudia Igler, Jens Rolff, Roland Regoes
    The number and effects of mutations leading to full drug resistance crucially determine treatment failure probability and should be used to inform antimicrobial treatment strategies with regard to avoidance of resistance emergence.
    1. Epidemiology and Global Health

    The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa

    Thomas S Churcher, Natalie Lissenden ... Hilary Ranson
    Mosquitoes with high levels of pyrethroid resistance reduce the ability of bednets to protect those using them and the wider community, which is predicted to substantially increase malaria cases.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle

    Alfonso Santos-Lopez, Christopher W Marshall ... Vaughn S Cooper
    Bacteria growing in biofilms evolve antimicrobial resistance via different pathways and generate greater genetic diversity than well-mixed populations, selecting fitter but less resistant genotypes.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Stable antibiotic resistance and rapid human adaptation in livestock-associated MRSA

    Marta Matuszewska, Gemma GR Murray ... Lucy A Weinert
    The dominant MRSA circulating in European livestock has stably maintained genes associated with resistance to antibiotic treatments over several decades and when it is transmitted to humans it can rapidly acquire genes that allow it to evade human immune responses.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

    Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
    An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.
    1. Ecology
    2. Microbiology and Infectious Disease

    Relationships between community composition, productivity and invasion resistance in semi-natural bacterial microcosms

    Matt Lloyd Jones, Damian William Rivett ... Thomas Bell
    Resident members of natural bacterial communities limit the growth of non-resident bacteria primarily by increasing overall community growth.

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