A data-driven within-host model reveals that different antibiotics are associated with divergent effects on antibiotic resistance carriage and abundance in hospitalised patients, with important implications for antibiotic stewardship.
Daniel J Fazakerley, Rima Chaudhuri ... David E James
Lower mitochondrial coenzyme Q was a consistent feature across multiple in vitro and in vivo models of insulin resistance and was sufficient to cause insulin resistance through increased mitochondrial oxidants.
A novel compartment model identifies the impact of malaria strain diversity on biogeographic drug resistance patterns, supported by empirical evidence.
Loss-of-heterozygosity mutations, but not aneuploidies, are linked to the evolution of drug resistance in Candida albicans isolated from immunocompromised patients.
The number and effects of mutations leading to full drug resistance crucially determine treatment failure probability and should be used to inform antimicrobial treatment strategies with regard to avoidance of resistance emergence.
Thomas S Churcher, Natalie Lissenden ... Hilary Ranson
Mosquitoes with high levels of pyrethroid resistance reduce the ability of bednets to protect those using them and the wider community, which is predicted to substantially increase malaria cases.
Alfonso Santos-Lopez, Christopher W Marshall ... Vaughn S Cooper
Bacteria growing in biofilms evolve antimicrobial resistance via different pathways and generate greater genetic diversity than well-mixed populations, selecting fitter but less resistant genotypes.
Marta Matuszewska, Gemma GR Murray ... Lucy A Weinert
The dominant MRSA circulating in European livestock has stably maintained genes associated with resistance to antibiotic treatments over several decades and when it is transmitted to humans it can rapidly acquire genes that allow it to evade human immune responses.
Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.