5,456 results found
    1. Developmental Biology
    2. Neuroscience

    The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

    Merve Deniz Abdusselamoglu, Elif Eroglu ... Jürgen A Knoblich
    Odd-paired (opa) is required for the progression of temporal patterning in Drosophila neural progenitors to regulate temporal identities via an incoherent feed-forward loop.
    1. Developmental Biology
    2. Neuroscience

    Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit

    Luis F Sullivan, Timothy L Warren, Chris Q Doe
    The Eyeless/Pax6 temporal transcription factor generates neuronal identity, connectivity, and flight navigation behavior within the conserved adult brain structure called the central complex.
    1. Developmental Biology
    2. Neuroscience

    Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

    Yinan Li, Anthony Osuma ... Paschalis Kratsios
    The terminal selector-type transcription factor UNC-3/Ebf partially modifies the suite of its target genes at different life stages to establish and maintain the identity of C. elegans motor neurons.
    1. Developmental Biology
    2. Neuroscience

    A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

    Brandon Mark, Sen-Lin Lai ... Chris Q Doe
    Neurons are mapped for developmental features (lineage, hemilineage, temporal identity) and connectomic features (morphology, synapse localization and connectivity) to reveal correlations that can be tested experimentally.
    1. Developmental Biology
    2. Neuroscience

    Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

    Sonia Q Sen, Sachin Chanchani ... Chris Q Doe
    Spatial factors generate neuroblast-specific open chromatin, thereby biasing the subsequent binding of transcription factors to produce neuroblast-specific neurons.
    1. Developmental Biology
    2. Neuroscience

    How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits

    Julia L Meng, Zarion D Marshall ... Ellie S Heckscher
    In vivo stem cell reprogramming in the well-studied stem cell NB7-1 using the classic temporal transcription factor Hunchback increases motor neuron number and re-specifies dendritic morphology and neuromuscular synaptic partnerships.
    1. Neuroscience

    Differential temporal dynamics during visual imagery and perception

    Nadine Dijkstra, Pim Mostert ... Marcel AJ van Gerven
    In contrast to perception, during visual imagery, there are no clear time-locked processing stages and imagery specifically overlaps with perceptual processing around 160 ms after stimulus onset and from 300 ms onwards.
    1. Neuroscience

    Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

    Mubarak Hussain Syed, Brandon Mark, Chris Q Doe
    A steroid hormone acts directly on brain neural progenitors to coordinately alter gene expression and specify neuronal and glial cell types.
    1. Cell Biology
    2. Developmental Biology

    Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming

    Ke Xu, Xiaodan Liu ... Yan Song
    Spatial and temporal cues intersect, likely via enhancer-promoter looping, to turn on a master identity switch that in turn dictates natural lineage reprogramming with high efficiency and temporospatial precision.
    1. Neuroscience

    Principal cells of the brainstem’s interaural sound level detector are temporal differentiators rather than integrators

    Tom P Franken, Philip X Joris, Philip H Smith
    Principal neurons of the brainstem nucleus comparing sound level at the two ears do not have the slow response properties previously attributed to them, but are instead specialized for fast weighing of excitation and inhibition.

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