15 results found
    1. Structural Biology and Molecular Biophysics

    ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

    Panpan Hou, Jingyi Shi ... Jianmin Cui
    ML277 exclusively enhances the AO state voltage-sensing domain (VSD)-pore coupling of KCNQ1 channels, providing an effective tool to investigate the voltge-dependent gating and new strategies for treating long QT syndrome.
    1. Biochemistry and Chemical Biology

    A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

    Magnus Chan, Harutyun Sahakyan ... David Fedida
    Characterization of an extra-membrane site in IKs formed by KCNQ1 S1, Pore and S6 domains and the near extracellular region of KCNE1, which forms a binding pocket for channel activators.
    1. Structural Biology and Molecular Biophysics

    KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site

    Johan E Larsson, H Peter Larsson, Sara I Liin
    An auxiliary subunit alters the effect of a family of small-molecule openers on a voltage-gated potassium channel by inducing structural re-arrangements that promote protonation of the drug molecule.
    1. Computational and Systems Biology

    Ear pinnae in a neotropical katydid (Orthoptera: Tettigoniidae) function as ultrasound guides for bat detection

    Christian A Pulver, Emine Celiker ... Fernando Montealegre-Z
    Located in the legs, the miniaturized katydid ears exhibit cuticular pinnae to only capture high-ultrasonic bat echolocation calls, but katydid also hear their own calls using alternative ear paths, which suggest that their ears operate in a colossal frequency range.
    1. Neuroscience

    Cell type-specific long-range connections of basal forebrain circuit

    Johnny Phong Do, Min Xu ... Yang Dan
    Whole-brain mapping of the basal forebrain circuits reveals a connection diagram with highly convergent inputs and divergent outputs.
    1. Ecology

    Foxtrot migration and dynamic over-wintering range of an Arctic raptor

    Ivan Pokrovsky, Teja Curk ... Martin Wikelski
    The dynamic over-wintering range of migratory birds, resulting from the newly described 'foxtrot migration' pattern, reveals potential errors in single mid-winter population assessments and highlights implications for their conservation status.
    1. Ecology
    2. Neuroscience

    Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar

    Rachel H Parkinson, Jennifer Scott ... Geraldine A Wright
    Bees are at risk of consuming harmful pesticides found in nectar because they cannot detect them using their mouthparts.
    1. Structural Biology and Molecular Biophysics

    Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

    Josip Ivica, Hongtao Zhu ... Lucia G Sivilotti
    The sulfonate analog of glycine is very efficacious in activating glycine channels and causes conformational changes in this pentameric ligand-gated channel that are similar to those produced by glycine itself.
    1. Biochemistry and Chemical Biology

    Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

    Maxime Louet, Marina Casiraghi ... Jean-Louis Banères
    A combination of state-of-the-art biochemical, biophysical, and computational methods revealed that water molecules play a central role in signal propagation through G protein-coupled receptors.
    1. Structural Biology and Molecular Biophysics

    Deciphering a hexameric protein complex with Angstrom optical resolution

    Hisham Mazal, Franz-Ferdinand Wieser, Vahid Sandoghdar
    Cryogenic super-resolution microscopy resolves the three-dimensional arrangement of individual fluorescent markers attached to protein complexes with Angstrom precision through their blinking behavior, polarization selection and a classification scheme.

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